青年人大肠癌nm23基因表达及其意义

Expression of nm23 Gene in Young Patients with Colorectal Carcinoma

目的 探讨青年人大肠癌预后差的可能机制。方法 应用免疫组化ABC法检测转移抑制基因nm2 3蛋白产物核苷二磷酸激酶 (NDPK)在大肠癌中的表达。分析 >40岁和≤ 40岁的病人间表达的差异及与预后的关系。结果 nm2 3 (NDPK)的阳性表达率 >40岁组明显高于≤ 40岁组 (P <0 0 5 )。nm2 3 (NDPK)的表达与生存率呈正相关 (P <0 0 5 ) ,与转移复发率呈负相关 (P <0 0 5 )。结论 nm2 3 (NDPK)可作为大肠癌预后的判断指标。nm2 3 (NDPK)的低表达预示着肿瘤的高侵袭性和转移性 ,其可能是青年人大肠癌预后差的原因。

Objective To explore the reasons of poor prognosis in young patients with colorectal carcinoma.Method The expressions of nm23(NDPK) in 82 cases of colorectal carcinoma were examined by immunohistochemical staining (ABC means).The relationship between nm23 expression and prognosis was analized between two groups—patients under or over 40 years old.Results The nm23(NDPK) positive rate in patients of over 40 was higher than that of other patients ( P <0 05).The survival rate was significant higher in the group with nm23 expression than without nm23 expression.The recurrent and metastatic rate in the group with nm23 expression was significant lower (P<0 05).Conclusions The nm23 gene can be used as a prognostic indicator in colorectal cancer.The lower expression of nm23 gene can predict the recurrent and metastatic potentiality of colorectal cancer.It may be a reason of poor prognosis in young patients.