5-Fu纳米炭示踪剂在结直肠癌手术中的应用价值

Application of activated carbon nanoparticles carrying 5-Fu in radical operation of colorectal carcinoma

目的探讨5-Fu纳米炭示踪剂在结直肠癌手术中的应用价值。方法选取结直肠癌手术患者66例,随机分为两组,其中观察组26例,术中应用5-Fu纳米炭;同期对照组40例,术中未应用5-Fu纳米炭。比较两组病理标本所检出的淋巴结数量及术后化疗所引起的毒副作用。结果观察组21例(80.77%)成功检测出前哨淋巴结,在15例淋巴结转移患者中,10例可检出前哨淋巴结并病理证实为转移,其他5例未检出前哨淋巴结。观察组病理标本中所检出的平均淋巴结个数(11.02±4.21)明显高于对照组(7.42±3.16,P<0.05);术后3年生存率(76.92%)高于对照组(52.50%,P<0.05);未见因使用5-Fu所引起的毒副作用。结论术中应用5-Fu纳米炭有利于结直肠癌的综合治疗,提高患者的生存率。

Objective To evaluate the outcomes of activated carbon nanoparticles carrying 5-Fu in radical operation of colorectal carcinoma.Methods Sixty-six patients with colorectal carcinoma were enrolled in this study.The activated carbon nanoparticles carrying 5-Fu were injected around the tumor regions before surgical resection in 26 patients（the labeling group）,and the other 40 patients（the control group）underwent the standard radical operation.The black-stained sentinel lymph nodes were observed.The numbers of lymph nodes detected in pathologic samples,side effects of chemotherapy after injecting 5-Fu bound to activated carbon nanoparticles and the survival rates after three years were compared between the two groups.Results Among 26 cases included,the SLN was identified successfully in 21（80.77%）.Number of lymphatic metastatic cases was 15,and within them,SLN metastasis was found in 10 cases,SLN was not found in the other five cases.The side effects were not found in all cases.The mean number of lymph nodes in pathological samples,and the three-year survival rate were significantly higher in labeling group than those in control group（11.02±4.21 and 7.42±3.16,76.92% and 52.50%,P0.05,respectively）.Conclusion Application of activated carbon nanoparticles carrying 5-Fu during radical operation may be a useful adjuvant therapy in the patients with colorectal carcinoma.