期刊文献+

健康人群CD_4^+CD_(25)^+调节性T细胞分布规律与年龄、性别的相关性研究 被引量:1

下载PDF
导出
摘要 目的探讨正常人CD4+CD2+5调节性T细胞与年龄、性别的相关性。方法采用流式细胞术检测74例男性和67例女性不同年龄组健康体检者的外周血CD4+CD2+5调节性T细胞数量。结果男性为(106.45±47.69)/μl,女性为(91.83±33.89)/μl,两者差异具有统计学意义(P<0.05)。在各年龄组的比较中,31~40岁,41~50岁年龄组均明显高于21~30岁年龄组(P<0.05);51~60岁年龄组值明显低于31~40岁年龄组(P<0.05)。在31~40岁年龄组男性显著高于女性,具有统计学意义(P<0.01)。结论 CD4+CD2+5调节性T细胞分布规律与年龄、性别有关。
出处 《福建医药杂志》 CAS 2011年第6期96-97,共2页 Fujian Medical Journal
基金 福建省卫生厅青年基金项目(2007-02-15)
  • 相关文献

参考文献11

  • 1Sakaguchi S,Sakaguchi N,Asano M,et al.Immunologic self-tolerante maintained by activated T cells expressing IL-2 receptor alpha chains (CD25).Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases[J].J Immunol,1995,155 (3):1151-1164.
  • 2Hori S,Nomura T,Sakaguchi S.Control of regulatory T cell development by the transcription factor Foxp3[J].Science,2003,299:1057-1061.
  • 3Shevach EM,McHugh RS,Piccirillo CA,et al.Control of Tcell activation by CD4+ CD25+ suppressor T cells[J].Immunol Rev,2001,182:58-67.
  • 4Seo N,Hayakawa S,Takigawa M,et al.Interleukin-10 expressed at early tumoursites induces subsequent generation of CD4+T regulatory cells and systemic collapse of ntitumourimmunity[J].Immunology,2001,103 (4):449-457.
  • 5Itoh M,Takahashi T,Sakaguchi,et al.Thymus and amtoimmunity:produc-tion of CD4+ CD25+ naturally anergic and suppressive T cells as a key function of the thymus in maintaining immunologic self-tolerance[J].J Immunol,1999,162 (9):5317-5326.
  • 6Horwitz DA,Zheng SG,Gray JD.The role of the combination of IL-2 and TGF-beta or IL-10 in the generation and function of CD4+ CD25+ and CD8 regulatory T cellsubsets[J].J LeukocBiol,2003,74 (4):471-478.
  • 7王志红,陈虎,刘广贤,冯凯,廖丽.人外周血CD4^+ CD25^+细胞体外扩增T细胞亚群及功能检测[J].同济大学学报(医学版),2008,29(4):53-57. 被引量:3
  • 8Ng WF,duggan PJ,Ponchel F,et al.Human CD4+ CD25+cells:a naturally occurring population of regulatory T cells[J].Blood,2001,98 (9):2736-2744.
  • 9Torcia MG,Santarlasci V,Cosmi L,et al.Functional deficit of T regulatory cells in Fulani,an ethnic group with low susceptibility to Plasmodium falciparum malaria[J].Proc Natl Acad Sci U S A,2008,105 (2):646-651.
  • 10贺健梅,邹潇白,彭瑾瑜,郑军,陈曦.湖南省苗族健康人群外周血CD3+、CD4+、CD8+T淋巴细胞正常参考值研究[J].中国感染控制杂志,2009,8(2):82-85. 被引量:7

二级参考文献23

  • 1刘帅凤,刘伟,陈杰,梁富雄,郭宁贞,黄达春,黎锋,于晓方,赖声汉,李杰.广西壮族自治区健康成年人T淋巴细胞亚群分类绝对计数及CD_4/CD_8比值调查[J].中国艾滋病性病,2004,10(6):413-415. 被引量:23
  • 2陈铁龙,桂希恩,邓莉萍,Caroline Teter,孙静.湖北成人CD_4、CD_8T淋巴细胞计数正常值调查及CD_4与总淋巴细胞数的相关性分析[J].中国艾滋病性病,2005,11(4):252-254. 被引量:35
  • 3陈巧英,李大金.CD4^+CD25^+调节性T细胞的生物学特性及功能[J].中国免疫学杂志,2007,23(1):89-92. 被引量:25
  • 4Tsegaye A, Messele T, Tilahun T, et al. Immunohematological reference ranges for adult Ethiopians [J]. Clin Diag Lab Immunol, 1999,6:410- 414.
  • 5Uppal S S, Verma S, Dhot P S. Normal values of CD4 and CD8 lymphocyte subsets in healthy Indian adults and the effects of sex, age, ethnicity and smoking [J]. Cytometry B Clin Cytom, 2003,52:32 - 36.
  • 6Alberto S, Germano G, Angela P, et al. An Italian national muhicenter study for the definition of a reference ranges for normal values of peripheral blood lymphocyte subsets in healthy adults [J]. Haematologica, 1999,84:499-504.
  • 7Leslie R B, Thomas L L, Matthias K, etal. Reference values for peripheral blood lymphocyte phenotypes applicable to the healthy adult population in Switzerland [J]. Europ J Haematol, 2004,72:203 - 212.
  • 8Zorn E. CD4^+ CD25^+ regulatory T cells in human hematopoietic cell transplantation [ J ]. Seminars Cancer Biol,2006,16 : 150 - 159.
  • 9ErmannJ, Hoffmann P, EdingerM, et al. Only the CD62L^+ subpopulation of CD4^+ CD25^+ regulatory T cells protects from lethal acute GVHD[ J ]. Blood,2005, 105 : 2220 - 2226.
  • 10Taylor PA,Lees CJ,Blazar BR,et al. The infusion of ex vive activated and expanded CD4^+ CD25^+ immune regulatory cells inhibit graft-verus-host disease lethality [J]. Blood,2002,99(10) :3493 - 3499.

共引文献16

同被引文献4

引证文献1

二级引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部