吸入伊洛前列素对初入海拔5200m青年肺通气功能的影响

Effect of inhaling iloprost on pulmonary function at 5200 m high altitude

目的:观察雾化吸入伊洛前列素溶液对初入海拔5 200 m地区青年肺功能的影响,为促进高原习服提供新的措施,预防急性高原病。方法:16名受试者自海拔1 400 m历时5 d进入5 200 m,进入后当天检测受试者的肺通气功能(FVC、FEV1、FEV1%、MMEF、PEF和MVV),检测后采用雾化吸入伊洛前列素溶液,每次5μg,每天4次,连续5 d。于吸入伊洛前列素溶液第5天再次检测受试者的肺通气功能。结果:雾化吸入伊洛前列素后,FVC(4.75±0.87 L vs 3.58±0.66 L),FEV1(4.16±0.73 L vs 3.38±0.45 L),MVV(155.19±18.85 L vs 132.12±16.27 L),均非常显著改善(P均<0.01);FEV1%(99.25±8.12 L vs 92.79±5.48 L),MMEF(7.18±1.96 L/s vs 5.69±1.37 L/s),PEF(9.46±2.25 L/s vs 7.53±1.69 L/s),均显著改善(P均<0.05)。结论:在高海拔地区雾化吸入伊洛前列素溶液能提高移居者的肺通气功能。有利于高原习服和预防急性高原病。

Objective：To explore the effect of inhaling iloprost on pulmonary function of transients reached 5 200 m altitude.Methods：Sixteen subjects reached chronometer spot（5 200 m） from 1 400 m altitude.Lung function was tested,including FVC,FEV1,FEV1%,MMEF,PEF and MVV.They inhaled iloprost four times daily for 5 days,the pulmonary function was tested at the fifth day.Results：Lung function were increased significantly（P0.01,P0.05）after inhaling iloprost：FVC（4.75±0.87 L vs 3.58±0.66 L）,FEV1（4.16±0.73 L vs 3.38±0.45 L）,MVV（155.19±18.85 L vs 132.12±16.27 L）;FEV1%（99.25±8.12 L vs 92.79±5.48 L）,MMEF（7.18±1.96 L/s vs 5.69±1.37 L/s）,PEF（9.46±2.25 L/s vs 7.53±1.69 L/s）.Conclusion：Iloprost can improve lung function of transients and accelerate adaptation at high altitude.