硝苯地平对高血压患者心脑血管事件影响的调查

Effects of Nifedipine of Cardiovascular Disease Events for Hypertensive Patients

目的 :研究硝苯地平治疗高血压是否增加心脑血管事件的发生率。方法 :对 2 197例高血压患者 3年药物治疗情况进行调查 ,入选 5 46 0人年 ,依据抗高血压药物分为硝苯地平组 (33.3% ) ,非钙拮抗剂组 (38.9% )及钙与非钙拮抗剂联合组 (2 7.8% ) ,统计各组观察期内发生脑卒中、急性心肌梗塞及冠心病猝死的频数。结果 :全组平均年龄 48.6岁 ,高血压降压效果总有效率 75 .4% ;发生心脑血管事件 6 4例 (11.7% ) ,心、脑血管事件之比为 1∶3.3,硝苯地平组、非钙拮抗剂组及钙与非钙拮抗剂联合组心脑血管事件发生率分别为 12 .7‰、11.8‰、10 .5‰ ,三组间无显著性差异 (P>0 .0 5 )。结论 :未发现硝苯地平增加心脑血管事件的危险 。

Objective:To study whether nifedipine treatment might increase incidence of cardiovascular events for hypertensive.Methods:Status of antihypertensive drugs therapy of 2 197 hypertensives for 3 years was analyzed.Totally 5 460 person years were observed.According to antihypertensive drugs used,the subjects were divided into 3 groups:nifedipine group(33 3%),non calcium antagonists group(38 9%) and nifedipine combined non calcium antagonists therapy group(27 8%).Events of stroke and coronary heart disease(CHD) including AMI and coronary sudden death were recorded.Results:Total effective rate of lowering blood pressure for antihypertensive drugs therapy was 75 4%.64 stroke events were recorded during 3 years,The ratio of CHD to stroke was 1∶3 3.The incidence rate of cardiovascular events for nifedipine,non calcium antagonists and nifedipine combined antagonists were 12 7‰,11 8‰,10 5‰,respectively.There was no significant difference among the 3 groups.Conclusion:The results suggested that cardiovascular risk be not increased by nifedipine therapy.Nifedipine could be use as a first line antihypertensive drug.