林州市饮用水诱变效应与食管癌死亡率的关系

Study on the Relationship Between the Mutagenic Efects of Drinking Water and Incidence of Esophageal Cancer in Linzhou County——A Prevalent Area

应用蚕豆根尖微核技术研究了林州市生活饮用水的诱变活性与食管癌死亡率的关系。结果表明该地区饮用的山泉水、溪沟渠河水中存在染色体畸变的物质 ,这类物质在各种饮水类型的水样中所诱发的蚕豆根尖微核效应强弱与居民食管癌死亡率大小一致 (r=1,P<0 .0 5 ) ,提示 :这些诱变剂的存在可能是导致食管癌高发的重要因素。从而为食管癌水土因素致病理论提供实验佐证。

The relationship between the mutagenic effect of drinking water and the incidence of esophageal cancer was studied in Linzhou county with micronucleus technique in the root tips of vicia faba. The results showed that there existed some substances that caused chromosome aberration in the mountainous drinking water of Linzhou county.Micronucleus effects on the root tips of vicia faba induced by the substances in different kinds of drinking water coincided with the mortality of esophageal cancer( r=1,P<0 01) .It suggested that the existence of these chemical mutants in the water may be the important factors that caused high mortality of esophageal cancer.It provided experimental evidence for the etiological theory of esophageal cancer that esophageal cancer was caused by the polluting drinking water.