乳腺浸润性导管癌组织中CAS蛋白表达的临床病理意义

Expression of CAS protein and its clinical significance in the invasive ductal carcinoma of the breast

目的研究乳腺浸润性导管癌组织中细胞凋亡易感蛋白(CAS)表达的临床病理意义。方法选取乳腺浸润性导管癌53例、普通导管增生20例、异型导管增生20例、导管原位癌10例、正常乳腺组织14例,应用免疫组化方法观察CAS蛋白的表达,并探讨CAS与乳腺癌临床病理因素的关系,分析CAS和HER2、ER、PR以及ki-67指数的关系。结果 CAS在正常乳腺、普通导管增生、异型导管增生、导管原位癌、浸润性导管癌中的阳性率逐渐升高,分别为14.3%、25.0%、40.0%、60%、75.5%(P=0.000),CAS、HER2均与乳腺癌组织学分级、核分裂像、淋巴结转移有关;CAS评分与ki-67指数(r=0.439,P=0.003)和HER2评分(r=0.598,P=0.000)正相关。结论 CAS与乳腺癌的发生、发展、增殖、淋巴结转移有关,可能作为反映乳腺癌生物学行为的肿瘤标记物,CAS蛋白的表达和HER2有一定的相关性。

Objective To investigate the expression of cellular apoptosis susceptibility（CAS） and its clinical significance in the invasive ductal carcinoma（IDC） of the breast.Methods Immunohistochemical method was used to observe the expression of CAS in 53 cases of IDC,20 usual ductal hyperplasia（UDH）,20 atypical ductal hyperplasia（ADH）,10 ductal carcinoma in situ（DCIS）,and 14 normal breast tissues.The correlations of CAS expression with HER2,ER,PR,and ki-67 index were analyzed.Results The positive rates of the CAS protein in normal breast tissues,UDH,ADH,DCIS and IDC were 14.3%,25.0%,40%,60%,and 75.5%,respectively（P0.001）.The expressions of CAS and HER2 were positively correlated with histologic grade,mitotic activity,and lymph node metastasis.The positive expression of CAS was correlated with ki-67 index（r=0.439,P0.01） and HER2（r=0.598,P0.001）.Conclusion High expression of CAS is closely correlated with the pathogenesis,progression and lymph node metastasis of breast carcinoma.CAS could be considered a marker of the biological behavior of breast carcinoma.Furthermore,CAS may be associated with HER2 expression.