LOX-1在抑郁大鼠主动脉中的表达及阿托伐他汀的干预实验

The Expression of Lectin Like Oxidized Low Density Lipoprotein Receptor-1（LOX-1）in Aorta of Depression Rats and the Intervention of Atorvastatin

目的 通过观察凝素样氧化低密度脂蛋白受体-1（LOX-1）在抑郁大鼠主动脉中的表达,探讨抑郁可能引起动脉粥样硬化（AS）的机制以及他汀类药物干预的影响.方法 通过慢性不可预见性应激（UCMS）建立抑郁模型,检测血清内皮功能标志物及免疫组化法检测主动脉LOX-1蛋白表达.结果 抑郁大鼠LOX-1表达明显升高,内皮功能受损,阿托伐他汀可使内皮功能得到改善.结论 LOX-1在抑郁大鼠主动脉中的表达增加,提示抑郁可能通过损伤血管内皮功能导致AS,他汀类药物干预可保护抑郁大鼠血管内皮.

Objective To investigate the expression of leetin like oxidized low density [ipoprotein receptor-1 （ LOX-1 ） in aorta of depression rats and ohserve the mechanism of depression induce to atherosclerosis（ AS} ,and the intervention of Atorvastatin. Methods Rat models were established by the unpredictable chronic mild stress（UCMS） proeedure,the makers of endothelial function in serum and the expreesion of LOX-I in aorta were detected by immune-ohistochemistr. Results The expression of LOX-I in depression rats was significantly higher than normal group,and showed endothelial dysfunction, Atorvastatin could inhibit the expression of LOX -1 and improved endothelial function. Conclusion The expression of＂ LOX-1 in depression rats increases,which reveal depression may induce AS through endothelial dysfunction,Atorvastatin can protect Vascular endothelia.