Ⅱ期宫颈癌术前介入化疗栓塞的近期疗效评价

The Short-term Clinical Effect of Preoperative Chemoembolization for Cervical Cancer in Stage Ⅱ

目的 探讨Ⅱ期宫颈癌术前介入化疗栓塞的临床疗效.方法 Ⅱ期宫颈癌患者19例,行术前超选择双侧子宫动脉栓塞,介入术后4～6周后行宫颈癌根治术加盆腔淋巴结清扫术,分析淋巴结转移、术中出血量、手术时间指标.并与22例单纯手术患者进行对照.结果 术前行化疗栓塞的患者临床症状均有不同程度的缓解,缓解率100％.两组术中平均出血量,手术用平均时间,淋巴结转移率比较,差异有显著性（P＜0.05）.观察组术后病理切片示肿瘤细胞退行性变,肿瘤细胞肿胀,核固缩,核膜消失,肿瘤组织结构松散,周边组织内有大量炎性细胞浸润.结论 宫颈癌术前行化疗栓塞术创伤小,可使肿瘤分期降低,提高手术切除率,是宫颈癌综合治疗的有效手段之一.

Objective To investigate the clinical effect of chemoembolization on cervical cancer in stage II before operation. Methods Ninteen patients of cervical cancer in stage II were treated by preoperative super-selective bilateral uterine artery Embolism, then 4 - 6 weeks after intervention, radical resection of cervical carcinoma and pelvic lymph node resection were peformed, and lymphatic metastasis, blooding amount in operation, operation time were analyzed. All the factors were compaired with those of 22 patients who were treated by operation only. Results The clinical symptoms of the patients who were treated by preoperative chemoembolization were relieved in varying degrees, and the rate was 100%. Blooding amount was （ 330 ~ 25 ） ml on average, which was lower than the （ 540 - 45） ml of pure operation group （ P 〈 0.05 ）, operation time was 4h ~ 25 min, and the pure operation group was 5h - 30min. Conclusions Preoperative chemoembolization has the advantage of small wound, it can reduce the tumour stage, and improve the operation resection. It is one of the effective comprehensive treatments about cervical cancer.