促肝细胞生长素对慢性重症肝炎肝纤维化的影响

The Effects of Hepatocyte Growth-promoting Factors on Heptotic Fibrosis of Chronic Severe Hepatttis

目的 :了解促肝细胞生长素 (pHGF)对慢性重症肝炎肝纤维化的影响。方法 :将 62例慢性重症肝炎随机分为pHGF治疗组 ( 3 0例 )和对照组 ( 3 2例 ) ,采用放免法 (RIA)检测两组治疗前后血清HA、Ⅳ -C、PCⅢ、和LN水平。结果 :治疗前两组HA、Ⅳ -C、PCⅢ和LN水平无显著差异 (P <0 .0 5 ) ;治疗 1～ 1.5个月后 ,pHGF组HA、Ⅳ -C和PCⅢ水平明显降低 (P <0 .0 5 ) ;而对照组仅HA降低 (P >0 .0 5 ) ,Ⅳ -C、PCⅢ和LN较治疗前进一步升高。治疗后pHGF组HA、Ⅳ -C和PCⅢ较对照组明显降低 (P <0 .0 5 )。结论

Aim:To probe the effects of Hepatocyte Growth-promoting Factors(pHGF)on the hepatic fibrosis of chronic severe hepatitis.Methods:62 patients with chronic severe hepatitis are divided random into two groups,one Group( n =30) was treated by pHGF and the other( n =32)by complex treatment.Sera HA,Ⅳ-C,PCⅢ and LN of two groups were detdcted by using RIA beforetreatment and after treatment.Results:pHGF can decrease signiffcantly serum HA,Ⅳ-C and PCⅢ level.Comparing to pretreatment and complex treatment,the differentiation of serum HA,Ⅳ-C and PCⅢ had obviously,signifficance( P <0.05).Conclusion:The results indicate that pHGF may inhibitthe hepatic fibrosis of chronic severe hepatitis. \ \