糖尿病患者及糖调节受损人群患龋状况的比较研究

Comparative study on caries in individuals with diabetes mellitus and impaired glucose regulation

目的:了解2型糖尿病(DM)患者、糖调节受损(IGR)人群和血糖正常人群患龋情况,探讨其易感因素。方法:对145名2型DM患者、140名IGR人员和149名血糖正常人员进行流行病学问卷调查、口腔检查和血糖、静态唾液流量、唾液pH值测定。结果:DM组、IGR组和对照组的患龋率分别为66.9%、72.1%、63.8%,三组之间比较,差异无统计学意义;龋均分别为3.79、2.44、2.81颗牙,DM组的龋均显著高于IGR组和对照组(P<0.05),IGR组的龋均与对照组比较,差异无统计学意义(P>0.05);龋失补牙数构成比DM组分别为25.6%,26.4%,48.0%,IGR组分别为28.1%、10.5%、61.4%,对照组分别为34.1%、28.2%、37.7%,DM组龋失补构成比与IGR组,与对照组比较,差异均有统计学意义(P<0.05);IGR组龋失补构成比与对照组比较,差异有统计学意义(P<0.05)。DM组和IGR组的唾液量(mL/10min)和唾液pH值均数显著低于健康对照组(P<0.05),而空腹血糖值均数显著高于健康对照组(P<0.05)。结论:DM人群比IGR人群和健康人群患龋严重,控制糖尿病将有助于降低龋齿数。

Objective： To explore the caries status and their predisposing factors for individuals with type 2 diabetes mellitus（DM）,with impaired glucose regulation（IGR） and with normal glucose tolerance（NGT） respectively.Method： One hundred and forty-five patients with DM,140 individuals with IGR and 149 individuals with NGT（served as control group） were randomly selected.Oral examination was carried out and fasting plasma glucose（FPG）levels,plasma glucose level of 2 hours post glucose-load（PG2h）,resting salivary flow rates,salivary pH value were tested.Result： For DM,IGR and control group,the caries rate were 66.9%,72.1%,63.8% respectively with no significant difference among them.DMFT（caries mean）in DM group was significantly higher than that in IGR and control group（P 0.05）.The means of resting salivary flow rate and salivary pH value in DM and IGR group were lower than in the control group;while the mean of FPG value in DM and IGR group were higher than in the control group（P 0.05）.Conclusion： Patients with DM have more possibilities of dental caries than individuals with IGR or healthy control.Controlling diabetes mellitus may help to reduce the number of dental caries.