宫颈癌筛查系统与液基细胞学检测在宫颈病变初筛中的研究

Cervical Cancer Screening System and Liquid Based Cytology Test in ervical Lesion Screening Study

目的:探讨宫颈癌筛查系统(TruScreen)与液基细胞学检测(TCT)在宫颈病变初筛中的应用价值。方法:对1201例患者依次进行TruScreen、TCT及宫颈活检病理学检查,将其病理结果与TruScreen和TCT结果对照分析。结果:TruScreen、TCT阳性结果分别为316例和207例,病理学检查阳性结果为115例。TruScreen、TCT检测的敏感度分别为81.7%、71.3%,特异度分别为79.6%、88.5%、假阴性率分别为18.3%、28.7%,假阳性率分别为20.4%、1 1.5%。TruScreen检查敏感度略高于TCT,差异无统计学意义(P>0.05)。结论:TruScreen的效果评价略优于TCT,具有较低的假阴性率及相对不高的假阳性率,有望成为我国宫颈病变初筛的独立方法。

Objective：To study the value of cervical cancer screening system and liquid based cytology test in detection of cervical lesions.Methods：Cervical cancer screening system,liquid based cytology test and pathological test were performed in a 1201 caaes,and the results of the former two were compared with pathological outcomes.Results：A total of 316,207 and 115 cases were shown as positive according to cervical cancer screening system,liquid based cytology test and pathological test respectively indicating sensitivity of 81.7%,71.3%;specificity of 79.6%,88.5%;false negative rate of 18.3%,28.7%：and false positive rate of 20.4%,11.5%for cervical cancer screening system and liquid based cytology test.Sensitivity of cervical cancer screening system was slightly higher man that of the liquid based cytology test.while the difference was insignificant（P0.05）.Conclusion：Efficacy of cervical cancer screening system is better than that of liquid based cytology test.With low false negative rate and comparatively low false positive rate.it might be used alone as primary screening method for cervical lesions in China.