亮丙瑞林、曲普瑞林治疗子宫肌瘤的随机对照研究

The Randomized Controlled Trial of Treatment of Uterine Leiomyoma by Triptorelin and Leuprorelin

目的:观察亮丙瑞林和曲普瑞林治疗子宫肌瘤的临床疗效。方法:采用临床随机对照试验,选择从2010年2月～2011年2月在我院诊断为子宫肌瘤患者104例,随机分为亮丙瑞林治疗组(n=52)和曲普瑞林治疗组(n=52),共治疗3个月。分别观察两组患者子宫与肌瘤体积,血清垂体激素和性腺激素水平以及血红蛋白和血清铁含量。结果:治疗前后子宫及最大子宫肌瘤体积比较发现,两组均明显减小(t=2.938,P=0.005;t=3.012,P=0.004)。两组促卵泡激素(FSH)、黄体生成素(LH)和孕激素(P)差异不明显。而亮丙瑞林组雌二醇治疗后显著低于曲普瑞林组,差异有统计学意义(t=335,P=0.031)。且治疗前后两组血红蛋白和血清铁含量均显著增高,而两组之间无显著差异。结论:两种药物临床疗效确切,治疗效果相当,亮丙瑞林降低血清E2的作用更明显。

Objective：To evaluate the clinical effectiveness of triptorelin and leuprorelin in the treatment of uterine leiomyoma. Methods：104 cases were selected that was diagnosed with hysteromyoma from Feb 2010 to Feb 2011.They were divided randomly to triptorelin group and leuprorelin group and researched by RCT along 3 months.The volume of uterus and hysteromyoma,FSH,LH,P and E2 also with Hb and Fe of serum were measured.Results：Compared with pre-treament the volume of uterus and hysteromyoma diminished si gnificantly（t=2.938,P=0.005;t=3.012,P=0.004）.FSH,LH and P were not changed obviosly between two groups whereas E2 in leuprorelin group was lower than it in triptorelin group（t=2.335,P=0.031）.Hb and Fe in serum were increased markably.Conclusion：The two drugs had both ideal curative effects.Leuprorelin had superior role of decreasing E2 in serum.