转化生长因子α在尖锐湿疣损害中的表达

The expression of transforming growth factor a in lesions of condyloma acuminatum

目的：探讨ＴＣＦ－α在尖锐湿疣（ＣＡ）发病中致细胞增生的作用。方法：采用免疫组化ＳＰ法检测３０例ＣＡ损害中ＩＧＦ－α的原位表达，并以２０例健康男性正常包皮组织作为对照。结果：两组ＴＣＦ－α表达阳性率相同；ＣＡ组ＴＧＦ－α表达阳性者中的表达程度显著高于对照组（Ｐ＜０．００１）；其过度表达率也明显高于对照组（Ｐ＜０．００５）。结论：ＣＡ组织细胞可合成与分泌较多的ＴＧＦ－α，在其发病中作为中间介质发挥致细胞增生的作用。

To investigate the role of transforming growth factor a(TGF- a) in cell proliferation in the pathogenesis of condyloma acuminatum(CA). Methods :The TGF-a expression in situ in lesions of 30 patients with CA and in normal prepuce tissue of 20 healthy men was detected by immunohistochemistry assay.Results:The positive rates of TGF-a expression in two groups were the same, but the expression strength and the strong positive rates in pos- itive TGF-a expression lesions of CA was much higher than those in normal prepuce tissue (P < 0.001 and P< 0.005 respectively).Conclusions:The cells in CA lesions may synthesize and secrete more TGF-a,which result in its prolif erative effects as a medium in the pathogenesis of the disease.