期刊文献+

血管内皮祖细胞与冠心病的研究进展

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摘要 近年来,冠心病已成为严重威胁人类健康的主要疾病之一,其致死率极高,在欧美国家已占到总人口死亡数的1/3~1/2。对本病的发病机制,目前多数学者支持"内皮损伤反应学说",认为反复的内皮细胞损伤是动脉粥样硬化的起始病变。自1 997年,Asahara等首次从循环外周血中分离得到能分化为血管内皮细胞的前体细胞,并将其命名为内皮祖细胞以来,已有大量临床前试验证明内皮祖细胞具有参与出生后血管新生及修复损伤内皮的潜能。
出处 《中国医药导刊》 2011年第11期1940-1941,1954,共3页 Chinese Journal of Medicinal Guide
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参考文献17

  • 1肖刚峰,张怀勤.新的组织工程种子细胞——内皮祖细胞[J].国外医学(生物医学工程分册),2005,28(6):329-332. 被引量:4
  • 2Prokopi M,Pula G,Mayr U.Proteomic analysis reveals presence of platelet microparticles in endothelial progenitor cell cultares. Blood . 2009
  • 3Case J,Mead LE,Bessler WK,et al.Human CD34+AC133+VEGFR-2+cells are not endothelial progenitor cells but distinct,primitive hematopoieticprogenitors. Experimental Hematology . 2007
  • 4Asahara T,Murohara T,Sullivan A,et al.Isolation of putative progenitor endothelial cells for angiogenesis. Science . 1997
  • 5Asahara T,Masuda H,Takahashi T,Kalka C,Pastore C,Silver M,Kearne M,Magner M,Isner JM.Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circulation Research . 1999
  • 6Hill JM,Zalos G,Halcox JP,et al.Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. New England Journal of Medicine, The . 2003
  • 7Ingram DA,Mead LE,Tanaka H,et al.Identification of a novel hierarchy of endothelial progenitor cells using human peripheral and umbilical cord blood. Blood . 2004
  • 8Peichev M,Naiyer AJ,Pereira D,et al.Expression of VEGFR-2 and AC133 by circulating human CD34+ cells identifies a population of functional endothelial precursors. Blood . 2000
  • 9Hur J,Yoon CH,Kim HS,et al.Characterization of two types of endothelial progenitor cells and their different contributions to neovasculogenesis. Arteriosclerosis . 2004
  • 10Heissig B,Hattori K,Dias S,et al.Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell . 2002

二级参考文献17

  • 1Arasaha T,masuda H,Takahashi T,et al.Isolation of putative progenitor endothelial cells for angiogenesis[J].Science,1997,275(5302):964-967.
  • 2Bertolini F,Mancuso P,Gobbi A,et al.The thin red line:Angiogenesis in normal and malignant hematopoiesis[J].Exp hematol,2000,28(9):993-1000.
  • 3Lin Y,Weisdorf D,Solovey A,et al.Origins of circulating endothelial cells and endothelial outgrowth from blood[J].J Clin Invest,2000,105:71-77.
  • 4Boyer M,Townsend LE,Vogel LM,et al.Isolation of endothelial cells and their progenitor cells from human peripheral blood[J].J Vasc Surg,2000,31(1 Pt 1):181-189.
  • 5Shirota T,He H,Yasui H,et al.Human endothelial progenitor cellseeded hybrid graft:Proliferative and antithrombogenic potentials in vitro and fabrication processing[J].Tissue Eng,2003,9(1):127-136.
  • 6Ingram DA,Mead LE,Tanaka H,et al.Identification of a novel hierarchy of endothelial progenitor cells utilizing human peripheral and umbilical cord blood[J].Blood,2004,104:2752-2760.
  • 7Gehling UM,Ergun S,Schumacher U,et al.In vitro differentiation of endothelial cells from AC133-positive progenitor cells[J].Blood,2000,95:3106-3112.
  • 8Vasa M,Fichtlscherer S,Aicher A,et al.Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease[J].Circ Res,2001,89:1-7.
  • 9Schmeisser A,Garlichs CD,Zhang H,et al.Monocytes coexpress endothelial and macrophagocytic lineage markers and form cord-like structures in Matrigel under angiogenic conditions[J].Cardiovasc Res,2001,49:671-680.
  • 10Kureishi Y,Luo Z,Shiojima I.The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals[J].Nat Med,2000,6(9):1004-1010.

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