冠心病冠状动脉病变程度与临床生化指标相关性研究

Study of Correlation between Clinical Biochemical Items and Coronary Heart Disease's Severity

目的:研究不同类型冠心病生化指标与冠状动脉病变程度相关性。方法:检测稳定型心绞痛、不稳定型心绞痛、急性心肌梗死和正常对照组研究对象血压、BG、TC、TG、LDL、HDL、LP(a)和hs-CRP水平,分析其与Gensini积分的相关性。结果:冠心病组患者BMI指数、血压、BG、TC、TG、LDL和LP(a)均高于对照组(P<0.05),TC、TG、LDL、HDL、Gensini积分和hs-CRP在冠心病各组间的差异具有统计学意义(P<0.05)。BMI指数、血压、TC、TG和LDL在冠心病组患者中与Gensini积分正相关(P<0.05),HDL呈负相关(P<0.05);hs-CRP在SAP组和UAP组患者中与Gensini积分无相关性,在AMI组正相关(P<0.05)。BMI指数、TC、TG、LDL、LP(a)和hs-CRP是Gensini积分的危险因素,HDL为保护因素。结论:BMI指数、血压、TC、TG和LDL与冠状动脉病变程度正相关,可作为其评估的临床生化指标。

Objective：To study the correlation between clinical biochemical items and coronary heart disease＇ s severity. Methods：Blood pressure（BP）,blood glucose（BG）,total cholesterol（TC）,triglyceride（TO）,low density lipoprotein（LDL）,high density lipoprotein（HDL）,lipoprotein a（LP（a）） and high sensitivity c reaction protein（hs-GRF） were detected in patients with coronary heart disease and healthy people.Results：BMI index,BE BG,TC,TG,LDL and LP（a） in patients with coronary heart disessse were higher than control group（P0.05）.TC.TG,LDL,HDL,Gensini score and hs-CRP in patients with coronary heart disease wete statistics different （P0.05）.BMI index,BP,TC,TG,and LDL correlated positively with Gensini score in patients with coronary heart disease,while HDL was negative.BMI index,TC,TG,LDL,LP（a） and hs-CRP were risk factors for Gensini score.Conclusion：BMI inc.ex,BP,TC,TG and LDL correlated positively with coronary heart disease＇ s severity and they could be severed as evaluation items for coronary heart disease.