院内获得性铜绿假单胞菌头孢哌酮/舒巴坦钠耐药性及相关因素分析

Analyze to Drug Resistance and Correlation Factor of Cepoperazonand-sulbactam on Hospital-acquiredpneumonia Pseudomonas Aeruginosa

目的:探讨院内获得性铜绿假单胞菌头孢哌酮、舒巴坦钠耐药性及相关因素。方法:选择146株院内分离的铜绿假单胞菌株,采用药敏板条法进行头孢哌酮/舒巴坦钠药敏实验,采用酸法进行产酶菌株检测.并对标本来源的相关因素进行调查,分析铜绿假单胞菌分布特点、头孢哌酮、舒巴坦钠耐药性及相关因素分析。结果:146株铜绿假单胞菌共栓出耐药菌株43株,耐药率为27.4%。感染来源内科系统构成比最高,感染部位呼吸道感染构成比最高,单因素分析结果显示,菌株产酶情况、感染部位、感染部位的慢性疾病、感染科别、用药频度、用药周期具有相关关系。结论:院内获得性铜绿假单胞菌头孢哌酮/舒巴坦钠耐药性其有特征性的分布特点.影响因素较多,在临床诊治中应综合分析。

Objective：To investigate the drug resistance and correlation factor of cepoperazonand-sulbaciam on hospitalacquiredpneumonia pseudomonas aeruginosa.Methods：146 strain of pseudomonas aeruginosa that were obtained from specimen were selected inhospital.susceptibility test to pseudomonas aeruginosa were taken with chronotropic acid mothod.and correlation factor of specimen were invested,distribution of pseudomonas aeruginosa and correlation factor of drug resistant to cepoperazonand-sulbactam were analyzed.Results：43 drug resistance strain were discovered in 146 strain of pseudomonas aeruginosa.rate of resistance strain was 27.4%, univariate analyse shown that generating enzymes of strain,position of infection,complicating chronic disease in infection position, division,frequency and period of using antibiotic was correlation factor of drug resistance on hospital-acquiredpneumonia pseudomonas aeruginosa.Conclusions：Disposition of pseudomonas aeruginosa with drug resistance was distinctive,influencing factor was major.and compositive analysis should be apple in clinic.