布地奈德混悬液雾化吸入治疗儿童急性上呼吸道感染疗效分析

Analysis of inhaling Pulmicort Respules on Acute Upper Respiratory Tract Inflammation in Children

目的:探讨布地奈德混悬液(普米克令舒)雾化吸入治疗儿童急性上呼吸道炎症临床疗效。方法:急性上呼吸道感染患儿180例,随机分成3组(每组60例),分别采用常规抗炎组(A组),常规抗炎组+雾化吸入地塞米松和盐酸氨溴索(沐舒坦)(B组),常规抗炎组+雾化吸入普米克令舒(C组)的方法进行治疗,2次/d.持续2周,比较上述3组咳嗽、憋气、声音嘶哑严重程度量表和咳嗽、憋气、声音嘶哑缓解率和咳嗽、憋气、声音嘶哑平均缓解时间的差别。结果:治疗前后咳嗽、憋气、声音嘶哑严重程度积分的下降幅度C组(2.3+0.8)显著高于B组(1.7+0.4)和A组(0.8+0.3)(p<0.05);咳嗽、憋气、声音嘶哑缓解率B组(80%)、C组(86.7%)显著高于A组(56.7%)(P<0.05),但B、C组无显著差异(p>0.05);咳嗽、憋气、声音嘶哑平均缓解时间C组(4.5+0.7)显著短与B组(6.3+0.8)和A组(10.5+0.8)(P<0.05)。结论:在常规抗炎的基础上雾化吸入普米克令舒对儿童急性上呼吸道感染的治疗有较好疗效,值得推广。

Objective：To evaluate the therapeutic effect of inhaling Pulmicort Respules on acute upper respiratory tract inflammation.Methods：180 children with upper respiratory tract infection were randomly assigned to usual anti-i aflammatory group （group A,60 patients）,usual anti-inflammatory plus inhalation of dexamethasone and mucosolvan（group B,60 patients）,and usual antiinflammatory plus inhalation of Pulmicort Respules（group C,60 patients） for 2 weeks.The score of cough,short of breath and hoarseness were compared by severity scale,so were the remission rate and the mean time to remission of：cough,short of breath and hoarseness. Results：The decrease of score of cough,short of breath and hoarseness in group C（2.3＋0.8） was significantly greater than that in group B （1.7＋0.4） and group C（0.8＋0.3）（p0.05）.The remission rates of cough,short of breath and hoarseness group B（80%） and C（86.7%） were significantly higher than those in group A（56.7%）（p0.05）,but there was no significant difference between group B and group C（p0.05）. The mean time to remission of cough,short of breath and hoarseness in group C（4.5＋0.7） was significantly less than that i n group B（6.3＋0.8） and C（10.5＋0.8）（p0.05）.Conclusion：usual anti-inflammatory plus inhalation of Pulmicbrt Respules could improve the clinical outcomes of children with acute upper respiratory tract infection.