摘要
目的 探讨肺耐药蛋白 (LRP)在大肠癌中的表达及其临床意义。方法 以免疫组化检测 2 4例大肠癌组织中的LRP表达情况。结果 2 4例大肠癌中 2 0例LRP阳性 ,阳性率为 83 .3 % ,高、中分化腺癌的LRP阳性率 ( 17/17)明显高于低分化腺癌 ( 0 /2 ) ,LRP表达与肿瘤部位、大小、淋巴结转移、浸润深度及Dukes分期无关。结论 LRP在大肠癌原发耐药中具有重要作用 ,LRP的测定有助于化疗药物的选择。
? Objective To detect the expression of lung resistance protein (LRP) in patients with colorectal cancer and its clinical significance.Methods The LRP was measured by SABC immunohistochemical staining in 24 cases of colorectal cancer.Results LRP expressed in 20 out of 24 specimens,the positive rate of LRP is 83.3%.The positive rate of LRP in well and moderate differentiated adenocarcinoma was higher than that in poorly differentiated carcinoma.There was no correlation between the LRP expression and tumor site,size,lymph node involvement,serosal invasion or Dukes′ stages.Conclusions Our findings indicate that LRP plays an important role in intrinsic drug resistance in the colorectal cacner,and the analysis of LRP can help to choose the more effective chemotherapy drugs. 〔
出处
《中国肿瘤临床与康复》
2000年第2期7-8,共2页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
结直肠肿瘤
腺癌
肺耐药蛋白
lung resistance protein
colorectal neoplasms
adenocarcinoma
