非癌疾患血清肿瘤标记物的测定及对瘤标特异性的评价

Specificity of serum tumor markers on non-carcinoma

目的 评价某些肿瘤标记物的特异性。方法 分别对 2 5例急性炎症、3 0例结核及 3 4例慢性炎症患者的 7种肿瘤标记物进行了测定 ,并以 5 0例肺癌为对照。结果 1.除CEA外 ,其他多数标记物在不少的非癌疾患血清水平中皆有明显的升高及较高的假阳性率 ,不少与肺癌相当或高于肺癌。如肺癌sIL 2R、TSGF、SP、β Mg、SA、及CA5 0的阳性率分别为 70 .0 %、80 .0 %、5 0 .0 %、42 .0 %、70 .0 %及 3 6.0 %。而急性炎症时它们的假阳性率分别为 88.0 %、10 0 .0 %、60 .0 %、3 6.0 %、72 .0 %及 2 5 .0 % ,结核病的sIL 2R为 73 .3 %、SP为 46.7%及 β Mg为 3 6.7% ,慢性炎症的 β Mg为 44.1%及CA5 0为 47.6%。 2 .不同的非癌疾患其含量及假阳性亦不同。一般以急性炎症最高 ,结核其次 ,慢性炎症最低。结论 不少的肿瘤标记物在一些非癌疾患中有较高的假阳性 ,特异性不高 ,应采取多种诊断措施排除它们的干扰。

? Objective To evaluate the interference of non carcinomous diseases on the speciality of tumor markers.Methods 7 tumor markers were assassed in 25 patients with acute inflammation,30 tuberculosis ,34 chronic inflammation,as well as 50 lung cancer patients as controls of malignancy.Results Except CEA,the serum contents of 6 tumor markers were significantly elevated and had rather high false positive rates,some of them,the levels and false positive rates were similar to or even higher than those of lung cnacer,for example, TSGF,sIL 2R,SP, β Mg,SA,CA50 in acute inflammation,the sIL 2R,SP,β Mg in tuberculosis,β Mg and CA50 in chronic inflammation.For different diseases,the levels and false positive rates were different,generally speaking,the acute inflammation was the highest,the chronic inflammation was the lowest and tuberculosis was in between.Conclusions In some non carcinomous diseases,the levels of some tumor markers were significantly elevated,which means,these disease had obvious interference on the speciality of some tumor markers. 〔