视紫红质在视网膜变性疾病中作用机制的研究进展

The Progress of Rhodopsin in Light Induced Retina Degeneration

视紫红质是感光细胞中的一种视色素,在光线的接收和视觉电位的产生方面具有重要的生理作用,视紫红质接到的过度光信号传导是光性视网膜变性的主要因素。本文就视紫红质的研究现状,及其在视网膜变性中的作用机制做一综述。

Light absorption by the visual pigment rhodopsin is required to initiate the phototransduction cascade.Absorption of excessive amount of light,however,may eventually lead to photoreceptor degeneretion by an apoptotic process.In some sense,light damage depends on the amount of rhodopsin available for bleaching during light exposure.This article reviews the role of rhodopsin in retina light injury and other related retinitis pigmentosa degeneration disease.