血清C-反应蛋白、尿酸和血脂检测在冠心病中的联合应用

Combined application of serum C-reactive protein,uric acid and serum lipids in patients with the coronary heart diseases

目的:探讨冠心病患者血清C-反应蛋白、尿酸与血脂联合检测的临床应用价值。方法:检测107例冠心病患者(40例急性心肌梗死、38例不稳定性心绞痛、29例稳定性心绞痛)血清脂类[TC、TG、HDL-C、LDL-C、ApoA、ApoB和Lp(a)]、C-反应蛋白(CRP)和尿酸(UA),并与40例健康对照组的对应指标进行比较。结果:稳定性心绞痛组、不稳定性心绞痛组和急性心肌梗死组CRP、UA、TC、TG、LDL-C、ApoB、Lp(a)水平均高于对照组;除稳定性心绞痛组的ApoA外,观察组的血清HDL-C、ApoA水平均明显低于对照组,且CRP和UA与TC、TG、LDL-C、ApoB、Lp(a)呈正相关,与HDL-C、ApoA呈负相关。结论:冠心病患者血清C-反应蛋白和尿酸与血脂代谢异常有相关性,三者联合检测对冠心病的预防、诊断及预后判断具有重要的临床价值。

Objective：To study the clinical application value of combination detection of serum C-reactive protein（CRP）,uric acid（UA） and lipids in patients with the coronary heart diseases.Method：The serum CRP,UA and serum lipids [ TC,TG,HDL-C,LDL-C,ApoA,ApoB,Lp（a）] of 107 cases of coronary artery diseases（including 40 cases of AMI,38 cases of USA and 29 cases of SA） and 40 cases of control group were detected and analyzed by t test.Results：The level of serum CRP,UA,TG,TC,LDL-C,Lp（a） and ApoB in patients with SA,USA and AMI were more higher than that of the healthy group,and the level of CRP and UA had positive relativity with TG,TC,LDL-C,Lp（a）,ApoB;except for ApoA in 29 cases of SA,HDL-C and ApoA descended evidently,and the level of CRP and UA had negative relativity with HDL-C and ApoA.Conclusion：The serum CRP and UA have relationship with abnormal of serum lipids and the combined application of serum CRP,UA and lipids has more important significance for the diagnosis,therapy and prognosis of coronary heart diseases.