摘要
目的:通过SD大鼠肝癌模型,探讨其MRI征象及其病理组织形态学的关系。材料与方法:13只SD大鼠肝癌模型共21个瘤灶,用1.5T超导MR机检查,观察MRI征象与其病理进行对照。结果:1.肿瘤细胞分级为Ⅱ级有17个瘤灶,T_1WI等信号或稍低信号、T_2WI稍高信号;肿瘤细胞分级为Ⅲ级的4个瘤灶中3个瘤灶T_1WI稍低信号、T_2WI高信号,另1个瘤灶T_1WI呈稍低信号、T_2WI呈稍高信号;2.T_2WI呈稍高信号的18个瘤灶在病理上肿瘤多伴小灶至小片坏死,T_2WI呈高信号的3个瘤灶伴大片坏死;3.MRI图像上T_1WI瘤内“更低信号区”的病理基础主要为坏死。结论:SD大鼠肝癌模型MRI征象能反映瘤内病理组织形态学改变。
Purpose: To evaluate the correlation of MRI manifestations with pathology by SD rat HCC model. Materials and methods: 21 tumors were found in 13 SD rat HCC Models by using 1 .5T superconduet MR scanner. MR features wen observed and compared with the pathology of rat liver samples Results: (1) 17 tumors were pathologically classified as grade Ⅱ , whieh presented isomtense or slightly hypomtense signal on T1WI and slightly hyperintense signal on T2WI; the rest 4 tumors classified as grade Ⅲ, in which presented slightly hypomtense signal on T1WI and hypermtense signal on T2WI, and the lart one presented slightly hypomtense signal on T1WI and slightly hyperin-tensc signal on T2WI. (2) 18 tumors with slightly hvpermtense signal on T2WI pathologically presented spot or small patch necrosis, massive necrosis was observed in the other 3 tumors with hypermtense signal on T2WI. (3) The pathological basis of 'more hypointensity area on T1WI was necrosis of tumors in different size and shape. Conclusion; The MR features reflects the pathological change's of tumors of SD rat HCC Model.
出处
《影像诊断与介入放射学》
2000年第1期14-17,共4页
Diagnostic Imaging & Interventional Radiology
