摘要
细菌产生 β内酰胺酶是抗生素耐药的最常见机制 ,β内酰胺酶对 β-酰胺抗生素临床应用的影响取决于 β酶的活性谱。 Bush分类法和 Frere分类法将 β-内酰胺酶分成 4种类 (A、B、C、D) ,临床上超广谱酶和染色体编码的头孢菌素酶 (Am p C酶 )对 β内酰胺抗生素最具影响。掌握细菌 β内酰胺酶的分类和不同种类 β酶菌区域性流行特征对于β内酰胺抗生素的疗效和抗菌药物的选用起着极为重要的作用。
lactamase production is a very common mechanism of antibiotic resistance.The impact of β lactamases on the clinical use of β lactam antibiotics depends on the spectrum of activity of the enzymes.The β lactamases can be divided into four classes(A,B,C and D) in Bush's classification and Frere's classification,the class A inclusing extended spectrum β lactamases and class C β lactamase generally have the most impact on clinical practice.Master classification of bacterial β lactamases and characteristics of regional prevalence of bacteria producting β lactamases that can play the major impact to therapeutic effect of β lactam antibiotic and selection of antiobics.
出处
《医学研究生学报》
CAS
2000年第1期56-58,共3页
Journal of Medical Postgraduates
关键词
Β-内酰胺酶
β内酰胺抗生素
分类
临床应用
lactamase
β lactam antibiotic
Classification
Prevalence
Clinical use
