80例宫颈锥切术后生育能力及妊娠结局临床分析

The cinical analysis of 80 cases with cervical conization on the outcome of subsequent fertility and pregnancy

目的探讨宫颈锥切术对宫颈上皮内瘤变(CIN)及原位癌患者生育能力及妊娠结局的影响。方法回顾性分析本院2002年1月～2012年1月收治的宫颈上皮内瘤变(CIN)及原位癌行宫颈锥切患者80例作为实验组,入选条件有生育要求且解除避孕大于1年,无不孕症史,且年龄在40岁以下。随机抽取同期在本院就诊正常的妇女80例作为对照组,均无宫颈疾病手术史。对两组患者的受孕情况以及妊娠结局进行对比分析。结果实验组和对照组受孕率的比较,实验组的受孕率为76.25%,对照组为88.75%,两组比较差异有统计学意义(P<0.05)。实验组和对照组妊娠结局的比较,除小于胎龄儿外,早产、流产、胎膜早破及剖宫产差异有统计学意义(P<0.05)。结论宫颈锥切术后对患者的妊娠能力有一定的影响,并增加早产、流产、胎膜早破及剖宫产的发生率。

Objective To research the influence of cervical conization of cervical intraepithelial neoplasia of getting（CIN） and carcinoma in situ fertility patients and the pregnancy.Methods Eighty patients with cervical cone cut and cervical intraepithelial neoplasia of getting（CIN） and carcinoma in situ were retrospective analysized from January 2002 to January 2012.It was for the test group,selected conditions have fertility requirements and remove contraception more than 1 year,no history of infertility,and age in less than 40 years old;In the same period,80 patients with normal women was as control group,there were no cervical disease surgeries.In two groups the conception of patients and the pregnancy outcome were compared and analyzed.Results The experimental group and control group conception rate were compared,the pregnant rate of the experimental group was 76.25%,and the control group was 88.75%,two groups of comparisons difference was statistically significant（P 0.05）.The experimental group and control group except for gestational age of less than the preterm premature rupture of membranes,abortion,broken and cesarean section was statistically significant difference（P 0.05）.Conclusion Cervical cone of patient pregnancy after cutting ability have certain effect,and increase preterm premature rupture of membranes,abortion,broken and the incidence of cesarean section.