多西他赛联合奈达铂、氟脲嘧啶治疗晚期鼻咽癌近期疗效观察

Observation of curative effect of docetaxel combined with nedaplatin and fluorouracil in patients with metastatic nasopharyngeal carcinoma

目的观察多西他赛联合奈达铂、氟脲嘧啶治疗晚期鼻咽癌的近期疗效和不良反应。方法 38例晚期鼻咽癌患者给予多西他赛与奈达铂、氟脲嘧啶联合治疗,多西他赛75mg/m2+0.9%氯化钠注射液250mL,静脉滴注1h,第1天;奈达铂90mg/m2+0.9%氯化钠注射液500mL,静脉滴注3h,第1天;氟脲嘧啶750mg/m2+5%葡萄糖注射液500mL,静滴4h,第1～5天;每3周为1个周期。结果 38例患者治疗2个周期后评价疗效,获CR3例(7.9%),PR25例(65.8%),SD6例(15.8%),PD4例(10.5%),总有效率为73.7%。最常见的毒副作用为骨髓抑制,Ⅲ～Ⅳ度粒细胞减少占78.9%,Ⅲ～Ⅳ度血红蛋白减少占15.8%,Ⅲ～Ⅳ度血小板下降占42.2%。结论多西他赛联合奈达铂、氟脲嘧啶治疗晚期鼻咽癌患者,疗效和安全性较高,毒性可以耐受。

Objective To observe the efficacy and adverse reactions of docetaxel combined with nedaplatin,fluorouracil in the treatment of patients with metastatic nasopharyngeal carcinoma.Methods Thirty-eight patients with metastatic nasopharyngeal carcinoma were treated with docetaxel combined with nedaplatin,fluorouracil,and received docetaxel 75 mg/m2＋0.9% sodium chloride injection 250 mL for 1 hour by intravenous dripping on 1st day;Nedaplatin 90 mg/m2＋0.9% sodium chloride injection 500 mL for 3 hours by intravenous dripping on 1st day;Fluorouracil 750 mg/m2＋5% glucose for 4 hours by intravenous dripping from 1st to 5th days;With one cycle every 3 weeks.Results Among 38 patients evaluated after two cycles,complete response CR in 3 cases（7.9%）,PR in 25 cases（65.8%）,SD in 6 cases（15.8%）,PD in 4 cases（10.5%）,and overall response rate was 73.7%.The most common side effect was myelosuppression,Ⅲ～Ⅳ leucopenia occurred in 78.9% of all cases,Ⅲ～Ⅳ degree of reduction in hemoglobin occurred in 15.8% of all cases,Ⅲ～Ⅳ degree of platelet decline occurred in 42.2% of all cases.Conclution The docetaxel combined with nedaplatin,fluorouracil regimen is an effective and safe therpy for patients with metastatic nasopharyngeal carcinoma,the toxicity can be well-tolerated.