中西医结合治疗难治性精神分裂症的临床研究

Integrative medicine clinical study of refractory schizophrenia

目的探讨中西医结合治疗难治性精神分裂症的效果。方法选取本院收治的80例难治性精神分裂症患者,将其随机平均分为两组,实验组行中西医结合治疗,对照组行常规西医治疗。疗程均为8周,在治疗前及治疗后2、4、8周末分别采用阳性与阴性症状量表(PANSS)评定疗效,并对患者治疗后采用TESS量表和ADL分级评估。结果两组药物疗效相比,从第4周末开始,两组的PANSS量表评分均已逐渐减少(P<0.05);第8周两组间相比实验组低于对照组(P<0.05)。两组相比,实验组治疗后ADL分级变化和TESS不良事件发生率均低于对照组(P<0.05)。结论中西医结合治疗难治性精神分裂症患者,功能恢复较好,能有效提高患者生活自理能力。

Objective To explore the combination of traditional Chinese and Western medicine in the treatment of refractory schizophrenia effect.Methods Eighty cases of refractory schizophrenia patients were randomly divided into 2 groups,experimental group was treated with integrated traditional Chinese and Western medicine treatment,control group were treated with routine Western medicine therapy.The course of treatment was 8 weeks,before and after treatment of 2,4,8 weeks respectively using the positive and negative symptom scale（PANSS） assessment of efficacy,and the patients after treatment by TESS scale and ADL grading evaluation.Results The two groups were compared from the drug efficacy,at the end of the fourth week,two group of PANSS scale score had been gradually reduced（P 0.05）;eighth weeks between the two groups compared to the experimental group than those in control group（P 0.05）.The two groups were compared,the experimental group after treatment of ADL grade changes and TESS adverse event rates were lower than those of the control group（P 0.05）.Conclusion Combined Chinese and Western medicine treatment of refractory schizophrenia patients has good function recovery effect and can effectively improve patients＇ self-care ability.