移植肾肾小球滤过率的检测和评估(附视频)

Assessment and detection of glomerular filtration rate in kidney transplant recipients(video)

探讨评估移植肾肾小球滤过率(GFR)的最佳方法,从而早期发现移植肾功能异常并适时干预,对提高肾移植受者的生活质量和长期存活具有重要意义。本文介绍了菊粉清除率、放射性核素法实测GFR,应用外周血清肌酐、血清尿素氮、肌酐清除率等间接评估GFR,以及通过公式估算GFR等各种目前常见的GFR评估方法的原理及其优劣;并根据肾移植受者的特殊情况分析了估算GFR公式的适用性。

In order to improve the quality of life and long-term survival in renal transplant recipients, it is of great importance to find the best method to assess renal glomerular filtration rate （GFR）, which can monitor graft functions and guide interventions at the early stage. In this paper, a systematic introduction and evaluation were made on several existing methods to assess GFR, including inulin clearance, radionuclide method measuring GFR, and indirect assessment of GFR （application of blood creatinine, blood urea nitrogen, and creatinine clearance rate）, as well as estimated GFR by the formula. Moreover, the applicability of formulas for estimating GFR in kidney transplant recipients with st3ecial circumstances was discussed.