持续皮下注射吗啡治疗晚期肿瘤中重度癌痛的镇痛效果研究

The research of the effect of morphine continuous subcutaneous injection in the controlled analgesia pump to treat severe pain in advanced cancer

目的研究持续皮下注射给药技术(持续皮下注射)治疗晚期癌症患者顽固性癌痛的有效性。方法应用自控镇痛泵持续皮下注射吗啡治疗不能口服强吗啡制剂的中、重度癌痛患者(治疗组),并与常规口服强吗啡制剂的癌痛患者(对照组)对比观察镇痛效果、合并辅助用药等指标。结果治疗组26例患者肿瘤病情重、生存期短,对照组28例一般状态相对较好、生存期较长;两组患者镇痛疗效无明显差别。结论持续皮下注射是可以有效控制不能口服吗啡制剂的晚期肿瘤患者顽固癌痛的有效方法 。

Objective To research the effect of the technology of continuous subcutaneous injection to treat severe pain in advanced cancer. Method For the treating group, patients who suffered with severe pain and cannot take oral morphine preparations were treated with morphine continuous subcutaneous injection in the controlled analgesia pump. In the controlling group, patients were given oral morphine preparations. Indicators were compared between the two groups like the effect of relieving pain and adjuvant drugs. Results The 26 patients in treating group were in severe progression and with short survival time. The 28 patients in controlling group were relatively in good condition and with long survival time. There was no difference between the two groups in the effect of relieving pain. Conclusion The method of morphine continuous subcutaneous injection in the controlled analgesia pump could control the severe pain of the advanced cancer patients who cannot take the oral morphine preparations.