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治疗晚期黑色素瘤的一种新的靶向药:Vemurafenib 被引量:1

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摘要 Vemurafenib(plx4032,RG7204)是小分子、口服可利用的B-RAF激酶抑制剂。临床前研究显示,它能选择地阻断RAF/MEK/ERK通道,对B-RAF突变的黑色素细胞有抑制作用,
作者 王尔兵
出处 《肿瘤药学》 CAS 2011年第4期400-400,共1页 Anti-Tumor Pharmacy
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参考文献4

  • 1Bollag G,Hirth P,Tsai J,et al.Clinical efficacy of RAF inhibitor needs broad target blockade in BRAF-mutant melanoma[].Nature.2010
  • 2Flaherty KT,Puzanov I,Kim KB,et al.Inhibition of mutated,activated BRAF in metastatic melanoma[].The New England Journal of Medicine.2010
  • 3Vultur A,villanueva J,Herlyn M.Targeting BRAF in ad-vanced melanoma:a first step toward manageable disease[].Clinical Cancer Research.2011
  • 4Chapman PB,Hauschild A,Robert C,et al.Improved survival with vemurafenib in melanoma with BRAF v600E mutation[].N EngJ.2011

同被引文献17

  • 1倪宗瓒.医学统计学[M]{H}北京:高等教育出版社,2003273.
  • 2Wierzbicka-Hainaut E,Sassolas B,Mourey L. Te-mozolomide and cisplatin combination in naive patients with metastatic cutaneous melanoma:results of a phase II multicenter trial[J].{H}MELANOMA RESEARCH,2010,(02):141-146.
  • 3Tarhini AA,Kirkwood JM,Gooding WE. A phase 2 trial of sequential temozolomide chemotherapy followed by high-dose interleukin 2 immunotherapy for metastatic melanoma[J].{H}CANCER,2008,(07):1632-1640.
  • 4Tarhini AA,Cherian J,Moschos SJ. Safety and effi-cacy of combination immunotherapy with interferon alfa-2b and tremelimumab in patients with stage IV melanoma[J].{H}Journal of Clinical Oncology,2012,(03):322-328.
  • 5Tarhini AA,Gogas H,Kirkwood JM. IFN-α in the treatment of melanoma[J].{H}Journal of Immunology,2012,(08):3789-3793.
  • 6Hansson J,Aamdal S,Bastholt L. Two different du-rations of adjuvant therapy with intermediate-dose inter-feron alfa-2b in patients with high-risk melanoma(Nordic IFN trial):a randomised phase 3 trial[J].{H}LANCET ONCOLOGY,2011,(02):144-152.
  • 7Mao L,Si L,Chi Z. A randomised phase II trial of 1 month versus 1 year of adjuvant high-dose interferon α-2b in high-risk acral melanoma patients[J].{H}EUROPEAN JOURNAL OF CANCER,2011,(10):1498-1503.
  • 8Kaufman R,Spieth K,Leiter U. Temozolomide in combination with interferon-alfa versus temozolomide alone in patients with advanced metastatic melanoma:a randomized,phase iii,multicenter study from the Derma-tologic Cooperative Oncology Group[J].{H}Journal of Clinical Oncology,2005,(35):9001-9007.
  • 9任庆,伍靖武,田秀荣,谢岳云.干扰素-α联合化疗治疗恶性黑色素瘤临床疗效观察[J].现代肿瘤医学,2009,17(1):112-114. 被引量:7
  • 10付艳,杜楠,孙君重,郝怡鑫,赵晖.替莫唑胺联合生物疗法预防晚期黑色素瘤脑转移临床分析[J].肿瘤防治研究,2009,36(2):150-152. 被引量:6

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