血清尿酸水平与永久性心房颤动的相关性研究

Study of the correlation between serum uric acid and permanent atrial fibrillation

目的探讨血清尿酸水平与永久性心房颤动之间的关系。方法选择2010年12月～2011年11月在笔者所在医院住院的永久性房颤患者50例作为研究组,同期住院窦性心律且无房颤病史的患者50例作为对照组。记录各组患者的年龄、性别、心血管病的危险因素、心脏彩超数据、用药史、传统炎症标志物和尿酸水平等。采用Logistic回归分析房颤发生的危险因素。结果 SUA在永久性房颤组(412.5±84.4)和对照组(302.5±62.4)之间差异有统计学意义(P<0.001),单因素回归分析分析显示年龄(OR=1.192,P<0.001)、高血压(OR=3.167,P=0.008),服用β受体阻滞剂(OR=3.881,P<0.001)、左室射血分数(OR=0.588,P<0.001)、左房内径(OR=3.051,P<0.001),SUA(OR=1.020,P<0.001)、高敏C反应蛋白(OR=3.366,P<0.001)与永久性房颤有显著性相关,多因素Logistic回归分析显示SUA(OR=1.616,P=0.011)和hs-CRP(OR=1.461,P=0.018)与永久性房颤有显著相关。结论血清尿酸可能是永久性房颤的危险因素,仍需要进行大样本深入的研究。

Objective To investigate the correlation between serum uric acid and permanent atrial fibrillation. Methods 50 cases of patients with permanent AF,who were hospitalized in affiliated hospital of Qingdao University from December 2010 to August 2011,were collected in the study,and 50 patients without AF were regarded as the control group.The baseline clinical data were detected including age,gender,risk factors of cardiology diseases,echocardiography,drugs,conventiona 1 inflammatory markers and serum uric acid level.Risk factors of AF were analyzed by univariate or multivariate logistic regression analysis. Results A significant variance in serum uric acid levels was evident between patients with permanent AF（412.5 ± 84.4）and control group（302.5 ± 62.4）（P 〈 0.001）.After univariate analysis,the following variates were significantly associated with prsence of permanent AF,age（OR=l.192,P 〈 0.001）,hypertension（OR=3.167,P=0.008）, 13 -blocker use（OR=3.881, P 〈 0.004）,left ventricular ejection fraction,increased left atrial diameter（OR=0.588,P 〈 0.001）,SUA（OR=1.020, P 〈0. 001 ）and C-reaction protein levels.（OR=3.366,P 〈 0.001 ）,After multivariate logistic gression analysis,only SUA（OR= 1.616,P=0.0 11 ） and CRP（OR=l.461,P 〈 0.018）were significantly associated with permanent AF. Conclusion SUA may be the risk factor for permanent AF.