帕罗西汀、逍遥散结合音乐疗法治疗女性更年期抑郁症的疗效分析

Efficacy of paroxetine,Xiaoyaosan combined with music in treatment of climacteric female with depression

目的探讨多途径干预对于女性更年期抑郁症的疗效。方法将100例患者随机分为两组,每组各50例,治疗组采用中、西药配合音乐疗法,对照组单纯采用西药治疗,6周后进行疗效、睡眠改善情况、焦虑水平以及安全性比较。结果经过治疗后,治疗组有效率为94.00%,对照组为86.00%,两组比较差异有统计学意义(P<0.05);治疗前两组HAMA评分、PSQI评分比较差异均无统计学意义(P>0.05),疗程结束后,治疗组的HAMA总分及精神性焦虑、躯体性焦虑得分下降程度均高于对照组(P<0.05),以及PSQI总分、睡眠质量、睡眠时间及睡眠效率改善程度较对照组具有统计学差异(P<0.05),而入睡时间及睡眠障碍则较之于对照组改善显著(P<0.01)。治疗组不良反应评分低于对照组(P<0.05)。结论西药结合中药辅以开郁音乐多途径治疗抑郁症,安全有效,适合临床推广。

Objective To explore the different approaches in treating the female climacteric with depression. Methods 100 patients were randomly divided into two groups, 50 cases in each group, the treatment group used in western medicine, music therapy, the control group by simple western medicine treatment, after the treatment 6 weeks, improving sleep, anxiety level and safety were compared. Results After treatment, the effective rate of treatment group was 94%, contrast group was 86%, the difference was significant between the two groups （P 〈 0.05）; in two groups before treatment HAMA score, PSQI score had not significant difference （P 〉 0.05）, after the end of treatment, the treatment group total score of HAMA and psychic anxiety, somatic anxiety score decreased was significantly higher than that of control group （P〈 0.05）, and PSQI scores, sleep quality, sleep time and sleep efficiency improvement than the control group there was significant difference （P 〈 0.05）, and sleep time and sleep disturbances are compared with the control group improved significantly （P 〈 0.01）. The treatment group adverse score was lower than that of control group （P 〈 0.05）. Conclusion Paroxetine and TCM therapy combined with music is a safe and effective way of affection to female climacteric with depression.