瑞舒伐他汀对急性脑梗死患者血浆炎症因子的影响

The effects of Rosuvastatin on plasma inflammatory cytokines in patients with acute cerebral infarction

目的探讨瑞舒伐他汀对急性脑梗死患者血浆炎症因子的影响。方法选择80例急性脑梗死患者,随机分为观察组和对照组各40例。均予常规对症治疗(降颅压、控制血压血糖、抗血小板、改善脑循环等)。观察组在此基础上加用瑞舒伐他汀10 mg,每天1次,连用8周。结果治疗8周后,观察组TC、TG和LDL-C水平较治疗前明显下降,HDL-C水平明显上升(P<0.05);而对照组治疗前后血脂无明显变化(P>0.05)。两组患者血浆hs-CRP、IL-6和TNF-α水平均较治疗前明显降低(P<0.05或P<0.01),且观察组降低的幅度较对照组更明显(P<0.05)。且观察组的临床有效率明显高于对照组(χ2=5.54,P<0.05)。结论瑞舒伐他汀治疗急性脑梗死的疗效肯定,能明显改善脑梗死部位缺血缺氧和缺损神经功能,作用机制与降低血脂、改善血管内斑块的炎症反应有关。

Objective To investigate the effects of Rosuvastatin on plasma inflammatory cytokines in patients with acute cerebral infarction. Methods Eighty cases of patients with acute cerebral infarction were randomly divided into control group and observation group. All patients were given conventional symptomatic treatments, including reducing the intracranial pressure, control of blood pressure and blood glucose, anti-platelet, improving cerebral circulation, et al. The observation group was given Rosuvastatin 10 mg qd orally for 8 weeks. Results After 8 weeks of treatment, TC, TG and LDL-C levels decreased significantly compared with those before treatment; HDL-C levels were significantly increased （P 〈 0.05） in observation group. While there were no statistically differences （P 〉 0.05） before and after treatment in the＇control group; Plasma hs--CRP, IL--6 and TNF--et levels decreased significantly compared with those before treatment （P 〈 0.05 or P 〈 0.01）, and they decreased more significantly in the observation group than in the control group （P 〈 0.05）; The total effective rate of observation group was significantly higher than that of the control group （X3=5.54,P 〈 0.05）. Conclusion Treatment of a- cute cerebral infarction with Rosuvastatin is effective, then resulting in the improvement of ischemia and hypoxia and de- fects of neurological function. Its mechanism may be through decreasing cholesterol and improving inflammation of blood vessel plaque.