阻塞性睡眠呼吸暂停综合征与血清抵抗素的相关性

Relevancy of serum resistin level and obstructive sleep apnea syndrome

目的探讨阻塞性睡眠呼吸暂停综合征与血清抵抗素的相关性,同时分析检测血清抵抗素的临床意义。方法对65例阻塞性睡眠呼吸暂停综合征患者和65例健康人血糖、血脂、胰岛素水平及血清抵抗素进行检测,分析血清抵抗素浓度与临床指标的相关性。结果 OSAS组患者的AHI、TG、FINS、HOMA-IR及抵抗素水平高于对照组,最低SaO2及HDL-C水平低于对照组,两组比较差异有统计学意义(P<0.05);血清抵抗素浓度与体重指数、空腹血糖、胰岛素抵抗及睡眠呼吸暂停低通气指数呈正相关,与最低SaO2呈负相关。结论 OSAS患者血清抵抗素浓度升高,其中BMI、FINS、HOMA-IR、AHI及SaO2是血清抵抗素水平升高的独立危险因素。

Objective To explore the correlation serum resistin level in patients with obstructive sleep apnea syndrome, and analysis the clinical signicicance of serum resistin. Methods The blood sugar, blood fat and serum resistin level were detected on 65 cases obstructive sleep apnea syndrome and 65 healthy people. The correlation serum resistin level in patients with obstructive sleep apnea syndrome were analyzed. Results AHI, TG, FINS, HOMA-IR and resistin level were higher in OSAS group than in control group, the lowest SaO2 and HDL-C levels were lower in OSAS group than in control group （P 〈 0.05 ）. Serum resistin levels was positively correlated with BMI, FPG, HOMA-IR and AHI and negatively correlated with SaO2. Conclusion Serum resistin level is higher in OSAS patients. BMI, FINS, HOMA-IR, AHI and SaO2 are indepen- dence hazard factors for serum resistin level.