控制性机械通气联合大剂量纳洛酮治疗外伤性急性弥漫性脑肿胀疗效观察

Curative effect observation of traumatic diffuse brain swelling treated with controlled mechanical ventilation combined with high-dose naloxone

目的探讨控制性机械通气联合大剂量纳洛酮治疗外伤性急性弥漫性脑肿胀的临床效果。方法选取2010～2011年我院收治的外伤性急性弥漫性脑肿胀患者70例,将其随机分为治疗组和对照组各35例。对照组患者仅在呼吸困难时应用机械通气来进行治疗;治疗组患者在使用控制性机械通气的基础上加用大剂量纳洛酮进行治疗。观察两组患者的治疗效果及生命体征、血糖、血乳酸等血液指标的改善情况。结果治疗组的治疗效果、生命体征、血糖值、血乳酸等均优于对照组。结论控制性机械通气联合大剂量纳洛酮可有效治疗外伤性急性弥漫性脑肿胀患者,改善其生命体征,缩短治疗时间,减少并发症的发生几率。

Objective To investigate the clnical effects of the traumatic diffuse brain swelling treated with controlled mechanical ventilation combined with high-dose naloxone. Methods Selected 70 cases of traumatic diffuse brain swelling patients in our hospital, and randomly divided them into two groups of treatment group and control group, and each group contained 35 cases of patients. The control group was given mechanical ventilation just when they were hard to breathe; while the treatment group was added high-dose naloxone on the basis of the controlled mechanical ventilation. The iprovement conditions of vital signs, blood glucose, blood lactate and other blood parameters of these two groups were observed. Results The vital signs, blood glucose, blood lactate of the treatment group were all better than those of the control group. Conclusion It can effectively treat the traumatic diffuse brain swelling patients for us to take the method of controlled mechanical ventilation combined with high-dose naloxone, which can improve the vital signs of the patients, shorten the treatment time and reduce the risk of complications.