脑出血继发脑梗死患者止凝血分子标志物检测临床意义

The significance of hemostatic molecular markers in cerebral hemorrhage secondary to infarction

目的探讨脑出血继发脑梗死止凝血分子标志物早期检测的意义以及脑出血后止凝血状态变化与继发脑梗死之间的关系。方法收集脑出血继发脑梗死患者20例为研究对象,随机抽取20例脑出血患者为脑出血对照组,20例为健康对照组。检测脑出血患者在继发脑梗死前的血浆纤维蛋白原(FIB)、红细胞压积(HCT)、血浆内皮素(ET-1)、P选择素(P-S)、蛋白C(PC)、D-二聚体(D-D)值。结果脑出血继发脑梗死组与脑出血组和健康对照组相比FIB分别为3.96±1.53/2.77±0.68、2.86±0.44(均P<0.05);P-S分别为22.4±4.07、17.98±3.69、14.96±2.93,与对照组比较,差异有高度统计学意义(P<0.01);P-C分别为3.24±1.25、5.70±1.52、6.56±1.64(均P<0.05)。结论脑出血患者止凝血分子标志物的检测对早期预测和诊断继发脑梗死以及判断预后有一定意义,以FIB、P-C、P-S三个指标较为明显。

Objective To investigate the changes of hemostatic molecular markers and their clinical significence in patients of cerebral hemorrhge secondary to infarction.Methods A series of hemostatic molecular markers in including plasma FIB,HCT,ET-1,P-selection,P-C,D-Dimer were measured in 20 cases of cerebral hamorrhage secondary to infarction and 20 cases of cerebral hemorrhage patients and 20 cases of normal people.Results Plasma levels of FIB（3.96±1.53,2.77±0.68,2.86±0.44,all P〈0.05）,P-S（22.4±4.07,17.98±3.69,14.96±2.93,compared with normal group,P0.01） and P-C（3.24±1.25,5.70±1.52,6.56±1.64,all P〈0.01） were elevated significantly in cerebral hemorrhage secondary to infarction group compared with that of control groups.Conclusion This suggested that hemostatic molecular markers,especially FIB,P-S and P-C,would help to diagnose cerebral hemorrhage secondary to infarction earlier and predict prognosis with important clinical value for cerebral hemorrhage patients,especially FIB,P-S,P-C.