氯吡格雷联合阿司匹林治疗老年冠心病的临床疗效

The clinical efficacy of clopidogrel combined whth asprin in teatment of elderly coronary heart disease

目的观察氯吡格雷联合阿司匹林治疗老年冠心病(CHD)的疗效及其安全性。方法 64例老年冠心病患者随机分为对照组和观察组各32例:对照组单纯阿司匹林治疗,观察组采用氯吡格雷联合阿司匹林治疗,总疗程4周,疗程结束后检测患者凝血4项,观察治疗期间的不良反应发生情况。结果治疗4周后,两组的PT和PA与治疗前均无显著性差异(P>0.05);治疗后两组APTT与治疗前相比有显著性差异(P<0.05),观察组与对照组相比有显著性差异(P<0.05)。结论氯吡格雷联合阿司匹林治疗抗血小板聚集效果显著,用于老年冠心病的治疗有效安全。

Objective To observe the clinical effect and safety of clopidogrel and asprin on elderly coronary heart disease.Methods Sixty-four cases were divided into the control group（n = 32） and the observe group（n = 32） by random.The control group took asprin.The observe group took asprin combine with clopidogrel.The platelet aggregation was measured after 4 weeks＇ treatment.Results There was no significant different in PT of both group contract with pre-therapy（P〈0.05）.APTT had significant different in both group contrast with pre-therapy（P〈0.05）.Otherwise,there was significant different between two groups（P〈0.05）.Conclusion Asprin combine with clopidogrel is safely and definitely in the treatment of elderly coronary heart disease.