摘要
目的了解铅对孕妇胎盘金属硫蛋白(MT)表达的影响,为预防胎儿铅中毒提供依据。方法选择早孕期(6～10周)的孕妇77例,检测其血铅水平,对其进行追踪,检测其分娩后胎盘MT的表达水平。结果 MT主要表达于胎盘组织细胞的胞浆,不同血铅水平孕妇的胎盘MT的表达不同(Hc=29.03,P<0.01);胎盘MT表达水平与血铅的浓度呈正相关(rs=0.55,Uc=2.443,P<0.05)。结论铅能诱导人胎盘组织MT的表达,其表达与孕妇的血铅水平有关。
Objective To understand the effect of blood lead on the expression of metallothionein（MT） in placenta of pregnant woman and provide an evidence for prevention of lead poisoning in fetus. Methods Seventy-seven early pregnant（6-10 weeks） women were selected for detection of their blood lead level and followed,the expression of MT in placenta was measured after delivery. Results MT mainly expressed in histocytic cytoplasm of placenta.The expression varied in pregnant women with different concentrations of their blood lead（Hc=29.03,P〈0.01）,showing a positive correlation between MT expression and the level of blood lead（rs=0.55,Uc=2.443,P〈0.05）. Conclusion Lead can induce MT expression in tissue of placenta,the expression is associated with the level of blood lead in pregnant women.
出处
《青岛大学医学院学报》
CAS
2012年第2期159-160,共2页
Acta Academiae Medicinae Qingdao Universitatis
关键词
铅
金属硫蛋白
孕妇
前瞻性研究
lead
metallothionein
pregnant woman
prospective studies
