摘要
目的探讨经皮冠状动脉介入治疗(PCI)病人术前、术后血清基质金属蛋白酶-2(MMP-2)表达的变化及意义。方法 130例冠心病病人,行支架置入术85例(PCI组),单纯冠状动脉造影45例(CAG组)。CAG组于术前1d、术后1d,PCI组分别于术前1d及术后1、7、28d,应用酶联免疫吸附试验(ELISA)方法检测血清MMP-2水平的变化。结果 PCI组病人术前1d及术后1、7、28d血清MMP-2水平持续增高,不同时间比较差异有显著性(F=26.16,q=10.45～14.80,P<0.01)。CAG组病人术前1d、术后1d血清MMP-2水平比较差异无显著性(P>0.05)。结论支架置入术后MMP-2表达持续升高,而降低MMP-2水平可预防再狭窄。
Objective To investigate the changes of serum concentrations of MMP-2 before and after percutaneous coronary intervention（PCI） in patients with coronary heart disease（CHD）. Methods This study consisted of 150 CHD patients,of whom,85 underwent PCI（PCI group）,45 underwent merely coronary angiography（CAG group）.Serum MMP-2 of patients in CAG group was detected by enzyme linked immunoassay one day before and one day after angiography,and that in PCI group was detected one day before and one,seven and 28 days after PCI procedure. Results The levels of serum MMP-2 in PCI group were continuously elevated from one day before PCI to one,seven and 28 days after the procedure,with a significant difference between different times（F=26.16,q=10.45-14.80,P〈0.01）,while no significant difference was observed in MMP-2 levels in CAG group before and after angiography（P〉0.05）. Conclusion The expression of MMP-2 ascends after stent placement.Restenosis can be prevented by lowering the concentration of MMP-2.
出处
《青岛大学医学院学报》
CAS
2012年第2期161-162,共2页
Acta Academiae Medicinae Qingdao Universitatis
