胃复安对胶囊内镜检查影响的临床研究

Effect of metolopramide on capsule endoscopy examination:a randomized study

目的:研究胃复安对胶囊内镜检查的影响。方法:将2009年6月至2010年6月期间接受胶囊内镜检查的116例患者随机分成2组,干预组患者在吞服胶囊后立即肌注胃复安针10 mg,对照组患者不予注射胃复安针。观察2组患者的胶囊胃通过时间、小肠通过时间、全小肠检查完成率等项目。结果:各有58例患者进入干预组和对照组。干预组有51例完成全小肠检查,全小肠检查完成率为87.9%,对照组有48例完成全小肠检查,全小肠检查完成率为82.8%。对照组和干预组胶囊平均胃通过时间分别为(32.45±29.63)min和(45.81±40.01)min,组间比较有统计学差异(P<0.05);小肠通过时间分别为(252.69±113.29)min和(258.75±83.83)min,组间比较无统计学差异(P>0.05)。结论:吞服胶囊内镜后肌注胃复安针10 mg可明显缩短胶囊胃通过时间,不影响小肠通过时间,可提高全小肠检查完成率。

Objective： To investigate the effect of metoclopramide on capsule endoscopy（CE） examination.Methods： Total 116 patients referred for CE were randomized into two groups with 58 patients in each group.In treatment group patients received 10 mg metoclopramide intramuscular injection after swallowing the capsule and in control group no metoclopramide was administered.The gastric transit time,small bowel transit time,complete endoscopy rate were observed in both groups.Results： The CE examination was completed in 51 patients of treatment group（87.9%） and 48 of control group（84.2%）.Mean gastric transit time was（32.45±29.63）min in treatment group and（45.81±40.01）min in control group,there was significant difference between two groups（P0.05）.Mean small bowel transit time was（252.69±113.29）min in treatment group and（258.75±83.83）min in control group,there was no significant difference between two groups（P0.05）.Conclusions： Metoclopramide may reduces gastric transit time,but not effect small bowel transit time,which suggests that it might increase the likelihood of complete small-bowel examination in patients undergoing capsule endoscopy.