铜绿假单胞菌注射液防治乳腺癌术后皮下积液的临床研究

Clinical research of piliated pseudomonas aeruginosa for breast cancer patients after operation with seroma formation

目的探讨应用铜绿假单胞菌注射液对乳腺癌患者术后皮下积液防治的效果。方法选取2010～2011年于我科确诊的女性乳腺癌接受根治术患者100例,均符合临床分期ⅡA～ⅢA期(T2-3N0-1M0),随机分成两组,试验组50例,接受改良乳腺癌根治同时予以铜绿假单胞菌注射液术中创面3mL,腋窝2mL,术后第2天在积液处局部皮下、残腔及残腔周围皮下注射,隔日1支,6天1个疗程。对照组:50例,常规进行手术治疗,术后伤口加压包扎(24小时)。比较两组患者术后皮下积液的发生率,患者术后的局部症状(疼痛、肿胀),积液的量,创面愈合(积液消失)的时间等。结果试验组切口局部疼痛感、肿胀程度较对照组明显减轻。试验组皮下积液的发生率为12%,对照组为30%。两组的积液发生率差异有显著性(P<0.05);试验组产生皮下积液的量也明显少于对照组(P<0.05);试验组出现皮下积液的患者创面愈合(积液消失)的时间也较对照组短,差异有显著性(P<0.05)。结论本研究结果证实,对乳腺癌患者术中与术后早期局部应用铜绿假单胞菌注射液可以预防术后并发症的发生,有利于患者术后创面愈合。

Objective To discuss the clinical effects about early application of piliated pseudomonas aeruginosa to seroma formation after operation for breast cancer patients.Methods Treatment group： 50 cases of women with breast cancer,during the operation,injected piliated pseudomonas aeruginosa 3mL to the surface of the would and 2mL in armpit;the next day after operation,do subcutaneous injection 1mL,once two days,6 day is a circle.The control group： selected 50 patients who did operation for breast cancer in 2010 randomly.For comparing and analyzing with treatment group.The seroma formation＇s occurring rate and disappearance time,the postoperative symptoms（pain,swelling,etc） were compared among two groups.Results The T group patients＇ symptoms（pain,swelling,etc） obviously relieve than C group;T group＇ incidence of seroma formation is 12%,the control group is 30%.The two groups＇ incidence of seroma formation are significant difference（P 0.05）;T group＇ quantity of seroma formation was also less than the control group;T group＇ wound healing fast than control group,and the differences are significant（P 0.05）.Conclusions The research revealed that early application of piliated pseudomonas aeruginosa can obviously reduce the produce of seroma formation and accelerate the wound healing after operation for breast cancer patients.