神经元特异性烯醇化酶(NSE),S-100蛋白对新生儿病理性黄疸诊断的意义

Significance of NSE and s-100 protein test for diagnosis and treatment of neonatal pathological jaundice

目的探讨神经元特异性烯醇化酶(NSE)、S-100蛋白的检测对于诊治新生儿黄疸的临床意义。方法随机选取我院儿科接收的新生儿高胆红素患者分为足月新生儿组、32周以下组、32～36周新生儿组各30人;用经典ELISA法检测血清中S-100蛋白、NSE含量。结果新生儿病理性黄疸病例其血清中NSE,S-100蛋白检测值均大幅升高,胎龄越小数值上升越大。结论通过对血清中NSE、S-100蛋白含量的检测,可以为新生儿病理性黄疸并发核黄疸的预防和诊治提供一定的依据。对减少新生儿中枢神经系统损害的发生率和对提高围产期医疗水平都具有重大意义。

Objective To discuss neuron specific enolase（NSE）,and s-100 protein test for diagnosis and treatment of neonatal pathological jaundice clinical significance.Methods We randomly selected pediatrics of high neonatal bilirubin patients into term newborns group,32 weeks the following group,32~36 weeks neonatal group of each 30 people;with intracranial infection,ischemia of ischemic brain newborns could not be included in it.Results S-100 proteins of neonatal pathological jaundice of the serum NSE rose sharply,smaller gestational age,more obvious data.Conclusions Through the serum NSE and S-100 protein content detection,which will offer some basis for neonatal pathological jaundice concurrent nuclear jaundice prevention and treatment,reduce the central nervous system damage and improve medical level perinatal.