降钙素原在感染性肺炎鉴别诊断中的价值

The value of PCT in differential diagnosis of infectious pneumonia

目的探讨降钙素原(PCT)在感染性肺炎鉴别诊断中的价值。方法检测80例细菌性肺炎、70例肺炎支原体肺炎和65例病毒性肺炎患者及50例健康人血清的PCT,对其结果进行分析,PCT的检测采用化学发光免疫分析法。结果细菌性肺炎组血清PCT浓度及阳性率明显高于肺炎支原体肺炎组、病毒性肺炎组及健康组,差异有显著性统计学意义(F=34.732,χ2=173.210,P<0.05),肺炎支原体肺炎组、病毒性肺炎组及健康组血清PCT浓度及阳性率的差异无统计学意义(F=1.847,χ2=0.278,P>0.05);细菌性肺炎组中,男、女性别PCT阳性率差异无统计学意义(χ2=0.356,P>0.05);细菌性肺炎组中,年龄在35天～81岁之间,PCT阳性率之间差异无统计学意义(χ2=0.01,P>0.05)。结论细菌性肺炎PCT的阳性率不受年龄、性别的影响;在感染性肺炎时,PCT可用于细菌性肺炎的鉴别诊断,但不能用于鉴别诊断肺炎支原体肺炎及病毒性肺炎。

Objective To explore the value of procalcitonin （PCT） in differential diagnosis of in- fectious pneumonia. Methods The concentrations of PCT in sera from 80 bacterial pneumonia cases, 70 Mycoplasmal pneumonia cases, 65 viral pneumonia cases and 50 normal（control group） serum samples. The detection of PCT was detected by chemiluminescence Enzymeimmunoassay. Results The concentra- tions and positive rate of PCT of bacterial pneumonia group was significantly higher than that of myco- plasmal pneumonia group, viral pneumonia group and control group. The difference was statistically sig- nificant （F~ 34. 732, Xz = 173. 210,P ~ 0.05）. The serum PCT concentrations and positive rate of my- coplasma pneumonia group, viral pneumonia group and control group had no significant differences （F= 1. 847, Xz = 0. 278,P ~ 0.05）. The positive rate of PCT bad no significant difference between male and female in the bacterial pneumonia （Zz = 0. 356,P 〉 0.05）. The positive rate of PCT from the age of 35 days to 81 years old had no significant difference in the bacterial pneumonia （x2 = 0.01, P 〉 0.05）. Con- elusions The positive rate of PCT in bacterial pneumonia is not affected by gender, ages. PCT could be used for differential diagnosis of bacterial pneumonia in the infectious pneumonia. But it is not a good in- dex to distinguish the mycoplasmal pneumonia from viral pneumonia.