氟西汀合并抗精神病药物治疗具有强迫症状精神分裂症患者的效果观察

Fluoxetine Combined with Antipsychotic Treatment of Schizophrenia with Obsessive-compulsive Symptoms Observed Effect

目的探讨具有强迫症状的精神分裂症患者采用氟西汀合并抗精神病药物治疗的临床效果。方法选择我院2009年5月至2011年5月收治的强迫症状的精神分裂症患者60例,随机分为两组,对照组采取抗精神病药物治疗,观察组在此基础上加用氟西汀治疗,对两组临床效果进行回顾性分析。结果与对照组比较,观察组PANSS治疗后总分明显下降,差异有统计学意义(P<0.05)。观察组总有效率为90%,高于对照组总有效率63.3%。两组治疗前Y-BOCS评分无明显差异,治疗后观察组下降明显高于对照组,差异有统计学意义(P<0.05),两组不良反应发生率无明显差异,均无严重并发症发生。结论氟西汀合并抗精神病药物治疗具有强迫症状精神分裂症患者,可提高治疗效果。

Objective To investigate patients with obsessive-compulsive symptoms in schizophrenia and the use of fluoxetine in all the clinical effects of antipsychotic treatment.Methods Our hospital from May 2009 to May 2011 were treated for obsessive-compulsive symptoms in schizophrenia,60 patients were randomly divided into two groups,control group taking antipsychotics,based on the observation group in the West plus fluoride statin therapy,the clinical effect of the two groups were analyzed retrospectively.Results Compared with control group,the observation group PANSS total score decreased significantly after treatment,the difference was statistically significant（P〈0.05）.Total effective rate was 90% higher than the total efficiency of 63.3%.Two groups before treatment Y-BOCS score was no significant difference was observed after the treatment group decreased significantly higher,the difference was statistically significant（P〈0.05）,two groups of adverse events was no significant difference,no serious complications.Conclusion Fluoxetine combined with antipsychotic treatment in patients with schizophrenia,obsessive-compulsive symptoms,can improve the therapeutic effect.