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细胞胆固醇流出通路研究进展 被引量：3

Research progress of cellular cholesterol effiux pathway
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摘要 动脉粥样硬化的形成是动脉壁内泡沫细胞逐渐沉积的慢性炎症过程。循环中的氧化脂质特别是氧化型低密度脂蛋白胆固醇，以及一些体液因子、细胞因子均可引起单核巨噬细胞表面的清道夫受体表达增加，单核巨噬细胞吞噬大量含胆固醇的脂质，胆固醇流出减少，形成泡沫细胞，并在内皮下聚集，从而促进动脉粥样硬化的发生。
作者 徐留建 杨小东 张剑梅 王明晓
机构地区 靖江市人民医院心内科 河北联合大学临床医学系 煤炭总医院
出处 《中国心血管病研究》 CAS 2012年第4期309-312,共4页 Chinese Journal of Cardiovascular Research
基金 首都医学发展科研基金（项目编号：2007-3127）
关键词 腺苷三磷酸结合盒转运体A1 腺苷三磷酸结合盒转运体G1 清道夫受体B1 膜孔扩散 ATP binding cassette transporterA1 ATP binding cassette transporterG1 Scavenger receptor B I Aqueous diffusion
分类号 R541.4 [医药卫生—心血管疾病]
  • 相关文献

参考文献22

  • 1谢宇光,石雪颖,于晓玲.血脂异常与血管内皮细胞损伤对动脉粥样硬化形成的协同作用[J].中国心血管病研究,2006,4(6):478-480. 被引量：14
  • 2Haidar B, Denism M, Marcil M, et al. apolipoprotein A- I ac- tivates cellular cAMP signaling through the ABCAI transporter. Biol Chem, 2004,279 : 9963-9969.
  • 3Ruan XZ, Moorhead JF, Femando R, et al. PPAR agonists pro- tect mesangial cells from interleukin 1-induced intraceUular lipid accumulation by activating the ABCA1 cholesterol efflux pathway. J Am Soc Nephrol,2003,14:593-600.
  • 4Adorni MP, Zimetti F, Billheimer JT, et al. The roles of differ- ent pathways in the release of cholesterol from maerophages. J Lipid Res, 2007,48 : 2453-2462.
  • 5Catalano G, Duchene E, Julia Z, et al. Cellular SR-B I and ABCA1-mediated cholesterol efflux are gender-specific in healthy subjects. J Lipid Res, 2008,49 : 635-643.
  • 6Mukhamedova N, Fu Y, Bukrinsky M, et al. The role of differ- ent regions of ATP-binding cassette transporter A1 in cholesterol eftlux. Biochemistry, 2007,46 : 9388-9398.
  • 7Chau P, Nakamura Y, Fielding CJ, et al. Mechanism of prebeta- HDL formation and activation. Biochemistry, 2006,45 : 3981-3987.
  • 8Vedhachalam C, Duong PT, Nickel M, et al. Mechanismof ATP-binding cassette transporter A1-mediated cellular lipid ef- flux to apolipoprotein A- I and formation of high density lipoprotein particles. J Biol Chem, 2007,282 : 25123-25130.
  • 9Patricia G, Anna EB, Ginny KW, et al. Importance of different pathways of cellular cholesterol efflux. Arterioscler Thromb Vasc Biol, 2003,23 : 712-719.
  • 10Foumier N, Atger V, Paul JL, et al. Human apo A IV overexpression in transgenic mice induces cAMP stimulated cholesterol efflux from J77g macrophages to whole serum. Artefioscler Thromb Vasc Biol, 2000,20 : 1283-1292.

二级参考文献31

  • 1吴开云,杨亚安,邢卫星.OX-LDL诱导内皮细胞条件培养液对内皮细胞VCAM-1和ICAM-1的影响[J].解剖学研究,2004,26(4):247-249. 被引量：3
  • 2杨玉霞,杨丽霞,齐峰,郭传明,石燕昆,魏玲,李丽俐.冠心病患者高密度脂蛋白胆固醇与冠脉病变的相关性研究[J].中国心血管病研究,2006,4(7):506-508. 被引量：13
  • 3徐晓萍,王震炜,徐磊,彭凤,于嘉屏.冠心病患者血浆高密度脂蛋白及其亚型的变化分析[J].检验医学,2006,21(4):320-323. 被引量：5
  • 4[1]Austin MA.Epidemiology of hypertriglgceridemia and cardiovascular disease.Am J cardiol,1999,83:166.
  • 5[4]Ross R,Agius L.The process of atherogenesis cellular and molecular interaction:From experimental animal models to humans.Diabetologia,2001,35; 124.
  • 6[5]Vasile E,Antohe F,Simionescu M,et al.Transport pathways of β-VLDL by aortic endothelium of normal and hypercholesterolemic rabbits.Atherosclerosis,2001,25:195.
  • 7[6]Shimamoto T.Contraction of endothelial cells as a key mechanism in atherosclerosis and treatment of atherosclerosis with endothelial cell relaxant.Atherosclerosis,2003,85:229.
  • 8[7]Nagase M,Abe J,Takahashi K,et al.Genomic organization and regulation of expression of the lectin-like oxidized low-density lipoprotein receptor (LOX-1) gene.J Biol Chem,2004,273:33702-33707.
  • 9[8]Chandler AB,Stuart J,Mahmud B,et al.Phagocytized platelet:a source of lipids in human thrombin and atherosclerotic plaque.Science,2001,134:251
  • 10[9]Mendelson ME.Role of platelet in cholesterol ester formation by U937 cells.J Clin Invest,2003,81:62.

共引文献24

同被引文献27

  • 1何雪峰,李晓辉,李淑慧,何翠瑶.三七总皂苷对小鼠巨噬细胞源性泡沫细胞形成的影响[J].中国药房,2007,18(30):2323-2325. 被引量：14
  • 2Oram JF,Heinecke JW.ATP-binding cassette transporter A1:a cell cholesterol exporter that protects against cardiovascular disease.Physiol Rev,2005,85:1343-1372.
  • 3Tall AR.Cholesterol efflux pathways and other potential mechanisms involved in the athero-protective effect of high density lipo-proteins.J Intern Med,2008,263:256-273.
  • 4Williams DL,Connelly MA,Temel RE,et al.Scavenger receptor BI and cholesterol trafficking.Curr Opin Lipidol,1999,10:329-339.
  • 5Zimetti F,Weibel GK,Duong M,et al.Measurement of cholesterol bidirectional flux between cells and lipoproteins.J Lipid Res,2006,47:605-613.
  • 6Zanotti I,Favari E,Bernini F.Cellular cholesterol efflux pathways:impact on intracellular lipid trafficking and methodological considerations.Current Pharmaceutical Biotechnology,2012,13:292-302.
  • 7Low H,Hoang A,Sviridov D.Cholesterol efflux assay.J Vis Exp,2012,61:e3810.
  • 8Zhang J,Sutang C,Blake RP,et al.Development of a cellbased,high-throughput screening assay for cholesterol efflux using a fluorescent mimic of cholesterol.Assay Drug Dev Technol,2011,9:136-146.
  • 9Sankaranarayanan S,Kellner-Weibel G,de la Llera-Moya M,et al.A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol.J Lipid Res,2011,52:2332-2340.
  • 10Schroeder F,Jefferson JR,Kier AB,et al.Membrane cholesterol dynamics:cholesterol domains and kinetic pools.Proc Soc Exp Biol Med,1991,196:235-252.

引证文献3

二级引证文献1

中国心血管病研究
2012年 第4期

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