Foxj1在脑外伤后的表达变化

The Expression of Foxj1 after Traumatic Brain Injury

目的:探讨脑外伤后Foxj1在脑组织中的表达变化及其意义。方法:建立大鼠脑外伤模型,利用Western blot和免疫组织化学方法检测脑外伤后Foxj1在脑组织中表达的变化。结果:Western blot显示大鼠脑外伤后,Foxj1的表达逐步增高,伤后3 d升至最高点,之后逐渐降低;免疫组织化学的结果与Western blot一致。结论:脑外伤后Foxj1在脑组织中的表达增高,这种增高的表达参与了脑外伤后脑组织的病理生理和生化变化。

Objective： The goal of this study was to evaluate the expression of Foxj1 in the central nervous system after Traumatic Brain Injury.Methods： The brain stab-injury models of rat were performed.Western blot and immunohistochemistry analysis were used to investigate the expression of Foxj1 at various times after injury.Results： Foxj1 proteins around lesion site increased gradually and reached its maximum at the 3d post-injury,after that,the expression level began to decline.Immunohistochemistry showed similar results as Western blot.Conclusions： The increased expression of Foxj1 may be involved in the pathophysiological and biochemical progression after Traumatic Brain Injury.