阻塞性睡眠呼吸暂停综合征与高血压临床关系分析

The Clinical Relationship Analysis between Obstructive Sleep Apnea Syndrome(OSAHS) and Hypertension

目的:研究阻塞性睡眠呼吸暂停综合征与高血压的临床关系及相关机制。方法:将258例鼾症患者分为三组:单纯鼾症对照组(N组)、单纯OSAHS组(O组)、OSAHS合并高血压组(O+H组)。对三组患者进行临床基础资料收集,ESS问卷调查及EP评分,多导睡眠监测及血压测定。结果:三组鼾症患者之间年龄、性别、吸烟、饮酒差异无统计学意义(P>0.05),OSAHS组及OSAHS+HT组体重指数及颈围明显高于单纯鼾症组,差异有统计学意义(P<0.05);与单纯鼾症组比较,OSAHS组及OSAHS+HT组的EP评分、AHI、LaSO2(%)、MSaO2、Ts90%差异明显有统计学意义(P<0.05);与对照组相比OSAHS组及OSAHS+HT组睡眠前后收缩压和舒张压升高,差异有统计学意义(P<0.05)。结论:阻塞性睡眠呼吸暂停综合征与高血压关系密切,慢性间歇缺氧是引起高血压的核心机制。

Objective： To research the clinical relationship and mechanism between obstructive sleep apnea syndrome（OSAHS） and hypertension.Method： 258 patients were allocated to pure treating sleep apnea（N） and Pure OSAHS（O） and OSAHS and hypertension（O＋H） according to patient＇s intention and condition.Three groups of patients with clinical foundation data collection,ESS questionnaire survey and EP score,polysomnography monitoring and blood pressure measurement.Results： The difference of which all three groups on age,sex,smoking,drinking was no significant difference（P0.05）.But compared with control group,OSAHS group and OSAHS ＋ HT group,the difference of BMI and NC was statistically significant（P0.05）;The difference of which OSAHS group and OSAHS ＋ HT group compared with the control group on AHI,Ts90,LsaO2,MsaO2 is statistically significant（P0.05）;The difference of which OSAHS group and OSAHS ＋ HT group compared with control group on systolic and diastolic blood pressure before and after sleeping,is statistically significant（P0.05）.Conclusion： We concluded that OSAHS is associated with hypertension closely,chronic intermittent hypoxia is the cardinal mechanism which causing hypertension.