TRPV1研究的新亮点:TRPV1剪接变体

The New Highlight of TRPV1: the TRPV1 Splice Variant

TRPV1是一种非选择性阳离子通道蛋白,可被伤害性热刺激、辣椒素和氢离子等所激活。由于TRPV1在痛觉传导(尤其是炎症情况下的痛觉传导)中起重要作用,所以TRPV1的研究对临床治疗有十分重要的意义,研究也越来越深入。因为TRPV1可被多种刺激所激活,人们推论其有多个剪接变体(splice variant),不久,即证实了此设想。本文对迄今为止发现的TRPV1剪接变体做一简单综述。

TRPV1（Transient receptor potential vanilloid type 1） is a nonselective cation channel that is activated by capsaicin,stimuli heat and proton.Because of its importance in the pain pathway,especially in case of inflammatory pain transmission,the study of TRPV1 is significant for clinical and medical therapy.For TRPV1 can be activated by a variety of stimuli,it is inferred and soon confirmed that they have more than one splice variant.In this article,we reviewed the splice variants discovered so far.