摘要
目的探讨sCD40L和CRP的含量与动脉粥样硬化性脑梗死(Atherosclerotic cerebral infarc-tion,ACI)面积、NIHSS量表评分之间的相关性。方法采用双抗体夹心酶联免疫法及比浊法检测63例ACI患者及30例体检健康者的血清sCD40L和CRP含量,采用SPSS16.0软件进行统计学分析。结果 ACI患者血清sCD40L和CRP含量显著高于正常对照组,且病情越重及脑梗死面积越大的患者,血清sCD40L和CRP含量就越高,入院即时和入院14 d血清sCD40L与CRP含量呈正相关,通过绘制ROC曲线得出,sCD40L曲线下面积(0.954)大于CRP曲线下面积(0.869),sCD40L特异度(100%)高于CRP(96.7%),sCD40L灵敏度(84.1%)也高于CRP(69.8%)。结论 sCD40L、CRP含量的改变可作为判断ACI病情的血清生物学指标。
Objective To investigate the correlation between the content of sCD40L and CRP and atherosclerotic cerebral infarction area,NIHSS scale score.Methods Serum sCD40L and CRP levels of 63 ACI patients and 30 healthy persons were tested by double antibody sandwich enzyme immunoassay and turbidimetric assay,SPSS 16 software was used for statistical analysis.Results ACI patients with serum sCD40L and CRP contents were significantly higher than in normal controls,and more advanced disease and cerebral infarction area more patients,the serum sCD40L and CRP content is higher,the instant and the 14 day of admission admission serum sCD40L and CRP levels were positively associated,by plotting ROC curves,the area under the sCD40L curve（0.954） is greater than CRP curve area（0.869）,sCD40L specificity（100%） was higher than that of CRP（96.7%）,sCD40L sensitivity（84.1%） over CRP（69.8%）.Conclusions SCD40L,CRP content change can be used to judge the ACI disease serum biological markers.
出处
《卒中与神经疾病》
2012年第2期91-96,共6页
Stroke and Nervous Diseases
