直肠癌患者手术前后外周血白细胞介素2活性及淋巴细胞转化水平的变化

Peripheral blood interleukin-2 activity and lymphocyte transformation in patients with rectum cancer before and after operation

目的 通过测定直肠癌患者外科切除术前后外周血白细胞介素２（ＩＬ－ ２） 活性及淋巴细胞刺激指数（ＬＳＩ） 的变化，了解患者机体免疫功能。方法 选取直肠癌患者２０ 例，分别在术前及术后７，１４，２１，２８ ｄ 抽取外周血测定ＩＬ－２ 活性及ＬＳＩ变化。结果 直肠癌患者外周血ＩＬ－ ２ 及ＬＳＩ均显著降低，术后７ ｄ 进一步降低，至术后１４ ｄ 逐渐恢复。结论 ①直肠癌患者机体免疫功能下降；②外科根治切除术可使机体在术后短期内免疫功能进一步降低，但随着时间延长可显示出促进恢复作用。

Objective To evaluate the immune function of patients with rectum cancer who underwent surgical resection.Methods Twenty patients with rectum cancer were selected. Peripheral blood was drawn before resection and 7,14,21 and 28 days after resection. Interleukin-2 (IL-2) activity and lymphocyte stimulation index (LSI) were measured. Results Both IL-2 and LSI were significantly decreased ( P <0 01) in patients with rectum cancer. After operation, IL-2 activity and LSI were further decreased on day 7, but began to increase after 14 days, and exceeded the preoperative levels after 28 days. Conclusion ①Immune function is impaired in patients with rectum cancer.②Surgical resection can improve immune function of these patients, although temporal exace rhation can occur.